{"id":9945,"date":"2024-05-14T08:28:00","date_gmt":"2024-05-13T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=9945"},"modified":"2024-05-14T13:14:04","modified_gmt":"2024-05-14T04:14:04","slug":"lets-study%e3%80%80%e6%a0%84%e9%a4%8a%e5%ad%a64%e3%80%80vitamin-d%e3%80%80vol-4","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=9945","title":{"rendered":"Let\u2019s Study\u3000\u6804\u990a\u5b664\u3000Vitamin D\u3000vol.4"},"content":{"rendered":"\n

\u300c\u7d9a\u304d\u306f\u6b21\u56de<\/a>\u300d\u3068\u66f8\u304d\u306a\u304c\u3089\u3001\u5927\u5206\u6642\u9593\u304c\u305f\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002

\u30d3\u30bf\u30df\u30f3D\u306e\u9aa8\u306b\u95a2\u3059\u308b\u4f5c\u7528\u4ee5\u5916\u306e\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u4f5c\u7528\u3068\u306f\u3001
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\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u6539\u5584\u30fb\u30fb\u30fb\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3084\u82b1\u7c89\u75c7\u306e\u6539\u5584
\u30fb\u3046\u3064\u306a\u3069\u306e\u30e1\u30f3\u30bf\u30eb\u75c7\u72b6\u306b\u52b9\u679c\u7684
\u3067\u3057\u305f\u3002

\u514d\u75ab\u529b\u306e\u5411\u4e0a\u3068\u3044\u3046\u70b9\u304b\u3089\u8a00\u3048\u3070\u3001
COVID-19\u306b\u95a2\u3057\u3066\u8a00\u3048\u3070
\u305f\u3068\u3048\u3070\u3001\u3053\u3093\u306a\u8a18\u4e8b\u304c\u3042\u308a\u307e\u3059\u3002
\u201dRole of vitamin D in preventing of COVID-19 infection, progression and severity\uff08COVID-19\u611f\u67d3\u3001\u9032\u884c\u3001\u91cd\u75c7\u5316\u4e88\u9632\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\uff09\u201d
\u51fa\u5178\u306f\u3001J Infect Public Health. <\/a>2020 Oct;13(10):1373-1380.<\/p>\n\n\n\n

Abstract\u3092PC\u306e\u7ffb\u8a33\u3067\u8f09\u305b\u3066\u307f\u307e\u3059\u3002
\u201dCOVID-19\u306e\u6d41\u884c\u306f\u4e16\u754c\u7684\u306a\u516c\u8846\u885b\u751f\u306e\u5371\u6a5f\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u611f\u67d3\u75c7\u306e\u9632\u5fa1\u56e0\u5b50\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u305d\u306e\u305f\u3081\u3001\u611f\u67d3\u3001\u9032\u884c\u3001\u91cd\u75c7\u5316\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u4e88\u9632\u4fdd\u5065\u5bfe\u7b56\u304c\u5207\u5b9f\u306b\u6c42\u3081\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u7dcf\u8aac\u3067\u306f\u3001COVID-19\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6025\u6027\u547c\u5438\u5668\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u304a\u3088\u3073\u91cd\u75c7\u5ea6\u306e\u8efd\u6e1b\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8ad6\u3058\u305f\u3002\u3055\u3089\u306b\u672c\u7814\u7a76\u3067\u306f\u30012020\u5e745\u670820\u65e5\u6642\u70b9\u306e\u6b27\u5dde20\u30ab\u56fd\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3068COVID-19\u75c7\u4f8b\u304a\u3088\u3073\u6b7b\u4ea1\u3068\u306e\u76f8\u95a2\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u8af8\u56fd\u306b\u304a\u3044\u3066\u3001\u5e73\u5747\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3068\u4eba\u53e3100\u4e07\u4eba\u5f53\u305f\u308a\u306eCOVID-19\u75c7\u4f8b\u306e\u9593\u306b\u6709\u610f\u306a\u8ca0\u306e\u76f8\u95a2\uff08p=0.033\uff09\u304c\u89b3\u5bdf\u3055\u308c\u305f<\/span>\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u56fd\u306eCOVID-19\u6b7b\u4ea1\u8005\u6570\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u76f8\u95a2\u306f\u6709\u610f\u3067\u306f\u306a\u304b\u3063\u305f<\/span>\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u72b6\u614b\u3068COVID-19\u306e\u91cd\u75c7\u5ea6\u3084\u6b7b\u4ea1\u7387\u3068\u306e\u76f8\u95a2\u3092\u793a\u3057\u305f\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u7814\u7a76\u3082\u3042\u308b\u304c\u3001\u4ea4\u7d61\u5909\u6570\u3092\u8abf\u6574\u3057\u3066\u3082\u76f8\u95a2\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u7814\u7a76\u3082\u3042\u308b<\/span>\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u6025\u6027\u30a6\u30a4\u30eb\u30b9\u6027\u547c\u5438\u5668\u611f\u67d3\u75c7\u3084\u80ba\u708e\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b<\/span>\u3002\u3053\u308c\u306b\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b\u65b9\u6cd5\u3068\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3084\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u3092\u5229\u7528\u3059\u308b\u65b9\u6cd5\u304c\u3042\u308b\u3002\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u88dc\u5145\u306f\u6025\u6027\u547c\u5438\u5668\u611f\u67d3\u75c7\u306b\u5bfe\u3057\u3066\u5b89\u5168\u3067\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b<\/span>\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u4e16\u754c\u7684\u5927\u6d41\u884c\u6642\u306b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u3066\u3001\u5faa\u74b025(OH)D\u3092\u81f3\u9069\u30ec\u30d9\u30eb\uff0875-125nmol\/L\uff09\u306b\u7dad\u6301\u3059\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u3079\u304d\u3067\u3042\u308b\u3002\u7d50\u8ad6\u3068\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3068COVID-19\u306e\u91cd\u75c7\u5ea6\u3084\u6b7b\u4ea1\u7387\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u306a\u3044\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u306f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3084\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u201d<\/p>\n\n\n\n

\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u9ad8\u3044\u3068\u3001
COVID-19\u306b\u304b\u304b\u308a\u306b\u304f\u3044\u53ef\u80fd\u6027\u306f\u3042\u308b\u3082\u306e\u306e\u3001
\u91cd\u75c7\u5ea6\u3084\u6b7b\u4ea1\u7387\u3068\u306f\u95a2\u9023\u304c\u306a\u304b\u3063\u305f\u69d8\u3067\u3059\u3002

\u3057\u304b\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u6b20\u4e4f\u3057\u3066\u3044\u308b\u4eba\u306f\u3001
\u80ba\u708e\u306e\u3088\u3046\u306a\u6025\u6027\u547c\u5438\u5668\u611f\u67d3\u75c7\u306e\u4e88\u9632\u306e\u305f\u3081\u306b\u3082
\u88dc\u5145\u3057\u305f\u65b9\u304c\u3044\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002

\u3067\u306f\u3001COVID-19\u306e\u5f8c\u907a\u75c7\uff08Long-COIVD\uff09\u306b\u5bfe\u3057\u3066\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f
\u305d\u308c\u306b\u5bfe\u3057\u3066\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u8ad6\u6587\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u201dInvestigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection – PubMed (nih.gov)<\/a>\uff08\u30d3\u30bf\u30df\u30f3D\u3068SARS-CoV-2\u611f\u67d3\u5f8c\u306e\u6301\u7d9a\u7684\u75c7\u72b6\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u308b\uff09\u201d
\u51fa\u5178\u306f\u3001Nutrients. 2021 Jul 15;13(7):2430.<\/a><\/p>\n\n\n\n

Abstract
The emergence of persistent symptoms following SARS-CoV-2 infection, known as long COVID<\/em>, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol\/L, with n<\/em> = 36 (24%) having levels 30-49 nmol\/L and n<\/em> = 14 (9%) with levels <30 nmol\/L. Fatigue was common, with n<\/em> = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D.<\/p>\n\n\n\n

\u8981\u65e8
\u9577\u3044COVID\u3068\u3057\u3066\u77e5\u3089\u308c\u308bSARS-CoV-2\u611f\u67d3\u5f8c\u306e\u6301\u7d9a\u7684\u306a\u75c7\u72b6\u306e\u51fa\u73fe\u306f\u3001\u533b\u7642\u30b7\u30b9\u30c6\u30e0\u306b\u65b0\u305f\u306a\u8ab2\u984c\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u4e3b\u306a\u7279\u5fb4\u306f\u3001\u75b2\u52b4\u3068\u904b\u52d5\u8010\u5bb9\u80fd\u306e\u4f4e\u4e0b\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u8abf\u7bc0\u3084\u81ea\u5df1\u514d\u75ab\u306b\u3082\u95a2\u9023\u3057\u3001\u591a\u65b9\u9762\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u6211\u3005\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u304cCOVID-19\u5f8c\u306e\u75c7\u72b6\u306e\u6301\u7d9a\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u7acb\u3066\u305f\u3002\u3053\u3053\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u3001Chalder Fatigue Score\u30016\u5206\u9593\u6b69\u884c\u8a66\u9a13\u3001modified Borg scale\u3067\u8a55\u4fa1\u3057\u305f\u75b2\u52b4\u304a\u3088\u3073\u904b\u52d5\u8010\u5bb9\u80fd\u306e\u4f4e\u4e0b\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u67fb\u3059\u308b\u3002\u591a\u5909\u91cf\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3068\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u95a2\u4fc2\u3092\u8a55\u4fa1\u3057\u305f\u3002COVID-19\u306e\u767a\u75c5\u5f8c79\u65e5\u76ee\uff08\u4e2d\u592e\u5024\uff09\u306b149\u4eba\u306e\u60a3\u8005\u304c\u30ea\u30af\u30eb\u30fc\u30c8\u3055\u308c\u305f\u3002\u30d3\u30bf\u30df\u30f3D\u5024\u306e\u4e2d\u592e\u5024\u306f62nmol\/L\u3067\u3001n=36\u4eba\uff0824\uff05\uff09\u304c30-49nmol\/L\u3001n=14\u4eba\uff089\uff05\uff09\u304c30nmol\/L\u672a\u6e80\u3067\u3042\u3063\u305f\u3002\u75b2\u52b4\u306f\u4e00\u822c\u7684\u3067\u3001n=86\u4eba\uff0858\uff05\uff09\u304c\u75c7\u4f8b\u5b9a\u7fa9\u3092\u6e80\u305f\u3057\u305f\u3002\u591a\u5909\u91cf\u56de\u5e30\u5206\u6790\u306e\u7d50\u679c\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u672c\u7814\u7a76\u3067\u8a55\u4fa1\u3055\u308c\u305f\u7d99\u7d9a\u7684\u306a\u4e0d\u5065\u5eb7\u306e\u6307\u6a19\u3068\u306e\u9593\u306b\u95a2\u4fc2\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001COVID-19\u5f8c\u306e\u6301\u7d9a\u7684\u306a\u75b2\u52b4\u3068\u904b\u52d5\u8010\u5bb9\u80fd\u306e\u4f4e\u4e0b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f<\/span>\u3002

\u30d3\u30bf\u30df\u30f3D\u306b\u3064\u3044\u3066\u8a71\u3092\u66f8\u304d\u51fa\u3057\u305f\u6642\u306b\u306f\u3001
\u3061\u3087\u3063\u3068\u671f\u5f85\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001
\u5f8c\u907a\u75c7\u306b\u306f\u3042\u307e\u308a\u95a2\u4fc2\u306a\u3044\u69d8\u3067\u3059\u3002

\u3057\u304b\u3057\u3001\u6b21\u306e\u3088\u3046\u306a\u8ad6\u6587\u3082\u3042\u308a\u307e\u3059\u3002

\u201dVitamin D: A Role Also in Long COVID-19?<\/a>\uff08\u30d3\u30bf\u30df\u30f3D\uff1a Long-COVID-19\u306b\u3082\u5f79\u5272\uff1f\uff09\u201d
\u51fa\u5178\u306f\u3001Nutrients. 2022 Apr 13;14(8):1625<\/a>

Abstract
Coronavirus disease 2019 (COVID-19) has quickly become a global pandemic. Reports from different parts of the world indicate that a significant proportion of people who have recovered from COVID-19 are suffering from various health problems collectively referred to as “long COVID-19”. Common symptoms include fatigue, shortness of breath, cough, joint pain, chest pain, muscle aches, headaches, and so on. Vitamin D is an immunomodulatory hormone with proven efficacy against various upper respiratory tract infections. Vitamin D can inhibit hyperinflammatory reactions and accelerate the healing process in the affected areas, especially in lung tissue. Moreover, vitamin D deficiency has been associated with the severity and mortality of COVID-19 cases, with a high prevalence of hypovitaminosis D found in patients with COVID-19 and acute respiratory failure. Thus, there are promising reasons to promote research into the effects of vitamin D supplementation in COVID-19 patients. However, no studies to date have found that vitamin D affects post-COVID-19 symptoms or biomarkers. Based on this scenario, this review aims to provide an up-to-date overview of the potential role of vitamin D in long COVID-19 and of the current literature on this topic.

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