{"id":9340,"date":"2023-06-08T08:28:00","date_gmt":"2023-06-07T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=9340"},"modified":"2023-06-08T04:41:30","modified_gmt":"2023-06-07T19:41:30","slug":"%e3%81%a1%e3%82%87%e3%81%a3%e3%81%a8%e6%b0%97%e3%81%ab%e3%81%aa%e3%82%8b%e8%ab%96%e6%96%87","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=9340","title":{"rendered":"\u3061\u3087\u3063\u3068\u6c17\u306b\u306a\u308b\u8ad6\u65871"},"content":{"rendered":"\n

\u3061\u3087\u3063\u3068\u6c17\u306b\u306a\u308b\u8ad6\u6587\u3092\u898b\u304b\u3051\u307e\u3057\u305f\u3002
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\u201dClass switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination<\/a>\uff08SARS-CoV-2 mRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u53cd\u5fa9\u306b\u3088\u308a\u3001\u975e\u708e\u75c7\u6027\u30b9\u30d1\u30a4\u30af\u7279\u7570\u7684IgG4\u6297\u4f53\u3078\u306e\u30af\u30e9\u30b9\u30b9\u30a4\u30c3\u30c1\uff09\u201d
\u51fa\u5178\u306fScience Immunology 22 Dec 2022 Vol 8, Issue 79
DOI: 10.1126\/sciimmunol.ade2798

\u3044\u3064\u3082\u306e\u3054\u3068\u304f\u3001\u30a2\u30d6\u30b9\u30c8\u30e9\u30af\u30c8\u306fDeepL\uff08\u7121\u6599\u7248\uff09\u3067\u8a33\u3057\u305f\u3082\u306e\u3067\u3059\u3002
\u201dRNA\u30ef\u30af\u30c1\u30f3\u306f\u3001\u91cd\u75c7\u6025\u6027\u547c\u5438\u5668\u75c7\u5019\u7fa4\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b92\uff08SARS-CoV-2\uff09\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306b\u5bfe\u3059\u308b\u6709\u52b9\u306a\u4e88\u9632\u7b56\u3067\u3042\u308b\u3002\u9ad8\u30ec\u30d9\u30eb\u306e\u4e2d\u548cSARS-CoV-2\u6297\u4f53\u306f\u3001\u30ef\u30af\u30c1\u30f3\u8a98\u767a\u514d\u75ab\u306e\u91cd\u8981\u306a\u69cb\u6210\u8981\u7d20\u3067\u3042\u308b\u3002\u6700\u521d\u306e2\u56de\u306emRNA\u30ef\u30af\u30c1\u30f3\u6295\u4e0e\u5f8c\u307e\u3082\u306a\u304f\u3001\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3G\uff08IgG\uff09\u53cd\u5fdc\u306f\u4e3b\u306b\u708e\u75c7\u6027\u30b5\u30d6\u30af\u30e9\u30b9IgG1\u304a\u3088\u3073IgG3\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\uff0cSARS-CoV-2\u7279\u7570\u7684\u306a\u6297\u4f53\u306f\uff0c2\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6570\u30f5\u6708\u5f8c\u306b\u306f\u975e\u708e\u75c7\u6027IgG4\u304c\u5897\u52a0\u3057\uff0c3\u56de\u76ee\u306emRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3084SARS-CoV-2\u4e9c\u578b\u306e\u7834\u305f\u3093\u611f\u67d3\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\uff0e\u30b9\u30d1\u30a4\u30af\u7279\u7570\u7684IgG\u6297\u4f53\u306e\u3046\u3061IgG4\u6297\u4f53\u306f\uff0c2\u56de\u76ee\u63a5\u7a2e\u76f4\u5f8c\u306e0.04\uff05\u304b\u30893\u56de\u76ee\u63a5\u7a2e\u5f8c\u671f\u306b\u306f19.27\uff05\u306b\u5e73\u5747\u7684\u306b\u4e0a\u6607\u3057\u305f\uff0e\u3053\u306eIgG4\u6297\u4f53\u306e\u8a98\u5c0e\u306f\uff0c\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305f\u540c\u7a2e\u307e\u305f\u306f\u7570\u7a2e\u306eSARS-CoV-2\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u5358\u7d30\u80de\u89e3\u6790\u304a\u3088\u3073\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u308a\u30013\u56de\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001\u30b9\u30d1\u30a4\u30af\u7d50\u5408\u30e1\u30e2\u30ea\u30fcB\u7d30\u80de\u96c6\u56e3\u306e\u4e2d\u306b\u3001\u30e1\u30e2\u30ea\u30fcB\u7d30\u80de\u5168\u4f53\u306e\u30ec\u30d1\u30fc\u30c8\u30ea\u30fc\uff08\u4e2d\u592e\u50241.3%\u3001IQR0.9\uff5e2.2%\uff09\u3068\u6bd4\u8f03\u3057\u3066\u304b\u306a\u308a\u306e\u983b\u5ea6\u3067IgG4\u30b9\u30a4\u30c3\u30c1B\u7d30\u80de\uff3b\u4e2d\u592e\u502414.4%\u3001\u56db\u5206\u4f4d\u7bc4\u56f2\uff08IQR\uff096.7\uff5e18.1%\uff09\uff3d\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002\u3053\u306e\u30af\u30e9\u30b9\u30b9\u30a4\u30c3\u30c1\u306f\u3001\u6297\u4f53\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u8caa\u98df\u304a\u3088\u3073\u88dc\u4f53\u6c88\u7740\u3092\u5a92\u4ecb\u3059\u308b\u30b9\u30d1\u30a4\u30af\u7279\u7570\u7684\u6297\u4f53\u306e\u80fd\u529b\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002Fc\u3092\u4ecb\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u514d\u75ab\u306b\u91cd\u8981\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001SARS-CoV-2\u306b\u5bfe\u3059\u308b\u5c06\u6765\u306e\u30d6\u30fc\u30b9\u30bf\u30fc\u514d\u75ab\u306a\u3069\u3001mRNA\u30ef\u30af\u30c1\u30f3\u3092\u7528\u3044\u305f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30ec\u30b8\u30e1\u30f3\u306e\u9078\u629e\u304a\u3088\u3073\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u201d

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2\u56de\u76ee\u63a5\u7a2e\u5f8c\uff08Post2nd\uff09\u3055\u3089\u306b\u4e0a\u6607\u3059\u308b\u3082\u3001
2\u56de\u76ee\u63a5\u7a2e\u304b\u3089210\u65e5\u5f8c\uff08FU post2nd\uff09\u306b\u5c11\u3057\u6e1b\u5c11\u3057\u3001
3\u56de\u76ee\u63a5\u7a2e\u5f8c\uff08Post3rd\uff09\u3067\u518d\u3073\u4e0a\u6607\u3001
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\"\"

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2\u56de\u63a5\u7a2e\u304b\u3089210\u65e5\u5f8c\u306b\u306f\u300119.27\uff05\u307e\u3067\u76f8\u5bfe\u7684\u306a\u91cf\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002

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IgG4\u304c\u4f55\u3092\u3057\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u3053\u3068\u306b\u3064\u3044\u3066\u306f
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\u201dWith respect to the control of viral infections, little is known regarding virus-specific IgG4 antibody responses. \uff08\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u5236\u5fa1\u306b\u95a2\u3057\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u7279\u7570\u7684\u306aIgG4\u6297\u4f53\u53cd\u5fdc\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\uff09\u201d
\u201dSo far, few studies on the role of vaccine-induced IgG4 responses against infectious diseases are available.\uff08\u3053\u308c\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308bIgG4\u5fdc\u7b54\u306e\u5f79\u5272\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u306a\u3044\uff09\u201d
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\u3061\u3087\u3063\u3068\u9577\u304f\u306a\u3066\u304d\u305f\u306e\u3067\u7d9a\u304d\u306f\u6b21\u56de\u306b\u3057\u307e\u3059\u3002

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