{"id":9230,"date":"2023-04-25T08:28:00","date_gmt":"2023-04-24T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=9230"},"modified":"2023-04-24T08:29:50","modified_gmt":"2023-04-23T23:29:50","slug":"%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e3%82%a2%e3%83%83%e3%83%97%e3%83%87%e3%83%bc%e3%83%885","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=9230","title":{"rendered":"\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u3064\u3044\u3066\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c85"},"content":{"rendered":"\n

\u524d\u3005\u56de\u304b\u3089\u306e\u7d9a\u304d\u3067\u3059\u3002

\u5b9f\u9a13\u533b\u5b66\u3000Vol.37\u3000No.12\u30002019\u3000\u5897\u520a\u53f7\u3000\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u75be\u60a3\u30fb\u8001\u5316\uff0c\u7f8a\u571f\u793e

\u3092\u8aad\u3093\u3067\u3044\u307e\u3059\u3002

\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u6297\u30a6\u30a4\u30eb\u30b9\u81ea\u7136\u514d\u75ab\u30b7\u30b0\u30ca\u30eb<\/span>p.145\uff1a
\u81ea\u7136\u514d\u75ab
\u3055\u307e\u3056\u307e\u306a\u75c5\u539f\u4f53\u304b\u3089\u8eab\u3092\u5b88\u308b\u3001\u521d\u671f\u5bfe\u5fdc\u3092\u62c5\u3046\u91cd\u8981\u306a\u751f\u4f53\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3002
\u4e00\u822c\u7684\u306b\u3001\u75c5\u539f\u4f53\u30bb\u30f3\u30b5\u30fc\u3068\u306a\u308bToll\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u3092\u4ecb\u3057\u305f
\u514d\u75ab\u5fdc\u7b54\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3082\u7d30\u80de\u5185\u306b\u304a\u3051\u308b
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\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304cRNA\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u81ea\u7136\u514d\u75ab\u306b\u3082
\u5bc6\u63a5\u306b\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\u3002<\/span><\/p>\n\n\n\n

\u6297RNA\u30a6\u30a4\u30eb\u30b9\u81ea\u7136\u514d\u75ab<\/span>
1\uff0eTLR\u7d4c\u8def
\u4e8c\u91cd\u9396RNA\uff08dsRNA\uff09\u304c\u4e3b\u306b\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u5185\u306b\u767a\u73fe\u3057\u3066\u3044\u308b
TLR-3\u6838\u9178\u30bb\u30f3\u30b5\u30fc\u306b\u3088\u308a\u521d\u671f\u8a8d\u8b58\u3055\u308c\u308b
\u21d2I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08INF-\u03b1\u3001INF-\u03b2\uff09\u3084\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\uff09\u3092\u7523\u751f\u8a98\u5c0e<\/p>\n\n\n\n

2\uff0eRIG-1\u7d4c\u8def
RIG-1\uff08retinotic acid-inducible gene 1)\u3068\u547c\u3070\u308c\u308b
\u5225\u306e\u6838\u9178\u30bb\u30f3\u30b5\u30fc\u306e\u50cd\u304d\u3067\u81ea\u7136\u514d\u75ab\u304c\u6d3b\u6027\u5316
\u3053\u306eRIG-1\u7d4c\u8def\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2<\/span><\/p>\n\n\n\n


\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u3088\u308b\u6162\u6027\u708e\u75c7\u5236\u5fa1<\/span>p.152\uff1a
\u708e\u75c7\u306f\u751f\u4f53\u9632\u5fa1\u306e\u305f\u3081\u306b\u5fc5\u9808\u3067\u3042\u308b\u304c\u3001
\u6162\u6027\u5316\u3059\u308b\u3068\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u3084\u8001\u5316\u306b\u304b\u304b\u308f\u3063\u3066\u304f\u308b\u305f\u3081\u3001
\u3088\u308a\u6b63\u78ba\u306b\u5236\u5fa1\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

\u6700\u8fd1\u306e\u7814\u7a76\u304b\u3089\u3001\u305d\u306e\u6b63\u78ba\u6027\u306e\u7dad\u6301\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3084
\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u304c\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b<\/span>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u708e\u75c7\u306e\u5f15\u304d\u91d1\u3068\u306a\u308b\u523a\u6fc0\u306b\u76f4\u63a5\u5fdc\u7b54\u3057\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u6a39\u72b6\u7d30\u80de\u306a\u3069\u304c\u3001
IL-1\u03b2\u306a\u3069\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u653e\u51fa\u3059\u308b\u3002
\u672c\u6765\u3053\u306eIL-1\u03b2\u306e\u7523\u751f\u306f\u4e00\u904e\u6027\u3067\u3042\u308b\u3079\u304d\u306a\u306e\u3060\u304c\u3001\u4f55\u3089\u304b\u306e\u969c\u5bb3\u3067\u3001
\u6301\u7d9a\u7684\u306b\u751f\u7523\u3055\u308c\u3066\u3057\u307e\u3046\u3068\u708e\u75c7\u304c\u5fc5\u8981\u4ee5\u4e0a\u306b\u9077\u5ef6\u3057\u3001\u6162\u6027\u708e\u75c7\u306b\u81f3\u308b\u3002<\/span>
\u305d\u306e\u969b\u3001\u7279\u306b\u4e0d\u9855\u6027\u306e\u6162\u6027\u708e\u75c7\u304c\u554f\u984c\u3067\u3001\u8efd\u5fae\u3067\u3042\u3063\u3066\u3082\u9577\u671f\u306b\u53ca\u3076\u708e\u75c7\u306f\u3001
\u751f\u4f53\u306e\u6052\u5e38\u6027\u3092\u5d29\u3059\u306e\u306b\u5341\u5206\u306a\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3001\u75be\u60a3\u306e\u767a\u75c7\u3092\u3082\u305f\u3089\u3059\u3002<\/p>\n\n\n\n

IL-1\u03b2\u3084\u305d\u308c\u306b\u985e\u4f3c\u306e\u69cb\u9020\u3092\u6301\u3064IL-18\u306e\u7523\u751f\u306b\u306f\u3001
\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u3002
\u305d\u306e\u4e2d\u3067\u3082NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u3001\u75c5\u539f\u6027\u5fae\u751f\u7269\u3084\u305d\u308c\u306b\u7531\u6765\u3059\u308b
PAMPs\uff08Pathogen-associated molecular patterns\uff09\u3084
\u30b7\u30ea\u30ab\u3001\u30a2\u30b9\u30d9\u30b9\u30c8\u3001\u4f4e\u6d78\u900f\u5727\u306a\u3069\u5916\u6765\u6027\u56e0\u5b50\u3084ATP\u3084\u5c3f\u9178\u306e\u7d50\u6676\u306a\u3069\u306e
\u5185\u56e0\u6027\u56e0\u5b50\u306b\u81f3\u308b\u6975\u3081\u3066\u591a\u69d8\u306a
DAMPs\uff08damege-associated molecular patterns\uff09\u306b\u3088\u3063\u3066\u523a\u6fc0\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u5358\u306b\u53d7\u52d5\u7684\u306b\u6a5f\u80fd\u3092\u5931\u3044\u306a\u304c\u3089
NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001
\u7a4d\u6975\u7684\u306b\u305d\u306e\u6d3b\u6027\u5316\u306b\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/p>\n\n\n\n

mtDNA\u306b\u3088\u308bNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u306b\u304a\u3044\u3066\u306f\u3001
mtDNA\u306f\u7d30\u80de\u5185\u306b\u304a\u3051\u308bDAMPs\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3002
\u3053\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u306eDAMPs\u3092\u3044\u304b\u306b\u5236\u5fa1\u3059\u308b\u304b\u304c
\u708e\u75c7\u3092\u5236\u5fa1\u3057\u3001\u6162\u6027\u708e\u75c7\u3092\u9632\u3050\u6709\u671b\u306a\u65b9\u7b56\u3068\u306a\u308b\u3002<\/span>


\uff1c\u7b2c3\u7ae0\uff1e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75be\u60a3\u306e\u8a3a\u65ad\u6280\u8853\u3068\u6cbb\u7642\u6226\u7565<\/span>

\u753b\u50cf\u8a3a\u65ad\u3068\u3057\u3066\u96fb\u5b50\u9855\u5fae\u93e1\u306e\u767a\u5c55\u3082\u3042\u308b\u69d8\u3067\u3059(p.160-173\uff09
\u4eca\u56de\u6ce8\u76ee\u306f\u3001\u201d\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fcGDF15<\/span>\u201d\uff08p.174)\u3002

\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u3067\u306f\u3001
\u767a\u75c7\u5e74\u9f62\u3001\u907a\u4f1d\u5f62\u5f0f\u3001\u75c7\u72b6\u30fb\u7f79\u60a3\u81d3\u5668\u30fb\u7f79\u60a3\u7d44\u7e54\u306e
\u3042\u3089\u3086\u308b\u7d44\u307f\u5408\u308f\u305b\u3092\u3068\u308a\u3048\u308b\u3053\u3068\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3002
\u7279\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9d\u5b58\u7684\u306a\u81d3\u5668\u7d44\u7e54\u306e\u75c7\u72b6\uff1a
\uff08\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3001\u5fc3\u7b4b\u3001\u9aa8\u683c\u7b4b\u3001\u5185\u5206\u6ccc\u3001\u8074\u899a\u306a\u3069\uff09\u304c\u51fa\u3084\u3059\u304f\u306a\u308b\u3002

\u5f93\u6765\u3001\u4e73\u9178\u30fb\u30d4\u30eb\u30d3\u30f3\u9178\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u304c\u3001
\u611f\u5ea6\u3082\u7279\u7570\u5ea6\u3082\u4f4e\u304f\u3001\u91cd\u75c7\u5ea6\u3068\u306e\u76f8\u95a2\u3082\u306a\u304b\u3063\u305f\u3002

\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001
GDF15\uff08growth differetiation factor 15\uff09\u3068\u3044\u3046\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/span>\u304c\u767a\u898b\u3055\u308c\u305f\u3002
\u3053\u308c\u306f\u611f\u5ea6\u30fb\u7279\u7570\u5ea698\uff05<\/span>\u3092\u6709\u3059\u308b\u8a3a\u65ad\u3001\u91cd\u75c7\u5ea6\u3001\u85ac\u52b9\u8a55\u4fa1\u306b\u6709\u7528\u3002


\u9577\u3005\u3068\u300e \u5b9f\u9a13\u533b\u5b66\u3000\u5897\u520a\u53f7\u3000\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u75be\u60a3\u30fb\u8001\u5316 \u300f\u3092\u8aad\u3093\u3067\u304d\u307e\u3057\u305f\u3002
\u81ea\u5206\u306e\u77e5\u3089\u306a\u3044\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u50cd\u304d\u304c\u305f\u304f\u3055\u3093\u66f8\u3044\u3066\u3042\u308a\u307e\u3057\u305f\u3002
\u3059\u3050\u3055\u307e\u4eca\u306e\u8a3a\u7642\u306b\u751f\u304b\u305b\u308b\u77e5\u8b58\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001
\u75c5\u6c17\u306e\u80cc\u666f\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u4e0d\u8abf\u3092\u8003\u3048\u3066\u304a\u304f\u3053\u3068\u304c\u5fc5\u8981\u306a\u5834\u5408\u3082
\u7d50\u69cb\u3042\u308a\u305d\u3046\u3067\u3059\u3002

\u3068\u3001\u305d\u3093\u306a\u3053\u3068\u3092\u8003\u3048\u3066\u3044\u305f\u3089\u3001
\u5b9f\u9a13\u533b\u5b66\u306e\u7f8a\u571f\u793e\u3055\u3093\u3001
\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u95a2\u3059\u308b\u3055\u3089\u306b\u65b0\u3057\u3044\u7279\u96c6\u53f7\u3092\u767a\u520a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002

\u5b9f\u9a13\u533b\u5b66\u3000 Vol.41\u3000No.5\u30002023\u3000\u5897\u520a\u53f7 \u3000\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3000\u75be\u60a3\u6cbb\u7642\u306e\u65b0\u6642\u4ee3
\"\"

\u65e9\u901f\u3001\u53d6\u308a\u5bc4\u305b\u3066\u3044\u307e\u3057\u305f\u3002
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