\u524d\u56de\u306f\u3001\u5916\u304b\u3089\u3084\u3063\u3066\u304d\u305fRNA\u3084
\u7d30\u80de\u306e\u4e2d\u3067\u8981\u3089\u306a\u304f\u306a\u3063\u305fRNA\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u8a8d\u8b58\u3055\u308c\u308b\u304b\u3092
\u4e2d\u5fc3\u306b\u304a\u8a71\u3057\u307e\u3057\u305f\u3002
\u3067\u306fDNA\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f
\u7570\u6240\u6027DNA\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3068\u3057\u3066\u306f\u3001
\u3082\u3061\u308d\u3093\u611f\u67d3\u306b\u3088\u3063\u3066\u5fae\u751f\u7269\u304b\u3089\u3082\u305f\u3089\u3055\u308c\u308bDNA\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u4ed6\u306b
\u7d30\u80de\u304c\u6709\u7cf8\u5206\u88c2\u3059\u308b\u969b\u306b\u5fae\u5c0f\u6838\uff08micronucleus\uff09\u3068\u547c\u3070\u308c\u308b\u69cb\u9020\u7269\u304c\u5f62\u6210\u3055\u308c\u3001
\u305d\u306e\u4e2d\u306b\u306f\u9ad8\u5ea6\u306b\u30e1\u30c1\u30eb\u5316\uff08\u4e0d\u6d3b\u5316\uff09\u3055\u308c\u305fDNA\uff08genomic DNA\uff0cgDNA\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u3066\u3001
\u3053\u308c\u304c\u7d30\u80de\u8cea\u5185\u3067\u5d29\u58ca\u3057\u305f\u969b\u306b\u51fa\u3066\u304f\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002
\u307e\u305f\u3001\u7d30\u80de\u5468\u671f\u975e\u4f9d\u5b58\u6027\u306b\u7d30\u80de\u8cea\u306b\u6392\u51fa\u3055\u308c\u308bgDNA\u3082\u3042\u308b\u3089\u3057\u304f\u3001
\u3053\u308c\u306f \u7d30\u80de\u30af\u30ed\u30de\u30c1\u30f3\u65ad\u7247\uff08cytoplasmic cromatin fragments\uff0cCCFs\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002
\u3042\u308b\u3044\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u306f\u72ec\u81ea\u306eDNA\uff08mtDNA\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001
\u3053\u308c\u3082\u7d30\u80de\u5185\u5916\u3067\u6d6e\u904a\u3059\u308b\u3068\u7570\u6240\u6027DNA\u3068\u306a\u308a\u307e\u3059\u3002
\u3053\u308c\u3089\u306e\u7570\u6240\u6027DNA\u3092\u8a8d\u8b58\u3059\u308b\u53d7\u5bb9\u4f53\uff08PRRs\uff09\u306b\u306f
\u30fb cGAS\uff08cyclic GMP-AMP synthese\uff09
\u30fb AIM2\u69d8\u53d7\u5bb9\u4f53\uff08AIM2\uff08absent in melanoma 2\uff09\u304a\u3088\u3073interferon gamma inducible protein 16\uff0cIFI16\uff09
\u30fb Nod\u69d8\u53d7\u5bb9\u4f53\uff08\u7279\u306bNod-like receptor family pyrin domain containig 3\u3000\u3068\u3001NLRP3\uff09
\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u304c\u3042\u308b\u305d\u3046\u3067\u3001\u305d\u308c\u305e\u308cRNA\u3068\u540c\u69d8\u306b\u5f79\u5272\u5206\u62c5\u304c\u3042\u308b\u69d8\u3067\u3059\u3002
dDNA\u306f\u304a\u3082\u306bcGAS\u3084AIM2\u306b\u3088\u3063\u3066\u51e6\u7406\u3055\u308c\u3001
mtDNA\u306f\u7d30\u80de\u8cea\u5185\u306b\u653e\u51fa\u3055\u308c\u305f\u3082\u306e\u306fcGAS\u3084NLRP3\u304c\u3001
\u7d30\u80de\u8cea\u5916\u306b\u653e\u51fa\u3055\u308c\u3048\u305f\u3082\u306e\u306f\u98f2\u307f\u8fbc\u307e\u308c\uff08\u30d5\u30a1\u30b4\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff09\u3001
\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u30fb\u30a8\u30f3\u30c9\u30ea\u30bd\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u69cb\u9020\u7269\u306b\u84c4\u7a4d\u3055\u308c\u3001
\u305d\u306e\u69cb\u9020\u7269\u306e\u819c\u306b\u5b58\u5728\u3059\u308bTLR9\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u308b\u307e\u3059\u3002
\u3053\u3046\u3057\u3066\u3001\u7570\u6240\u6027\u306eDNA\u304c\u8a8d\u8b58\u3055\u308c\u308b\u3068\u9632\u885b\u6a5f\u69cb\u304c\u50cd\u304d\u3060\u3057\u307e\u3059\u3002
\u4e00\u3064\u306fDNA\u5206\u89e3\u9175\u7d20DNase\u304cDNA\u3092\u3069\u3093\u3069\u3093\u3068\u5206\u89e3\u3057\u3066\u3044\u304d\u307e\u3059\u3002
\u307e\u305f\u3001\u305d\u308c\u3068\u306f\u5225\u306b\u6297\u30a6\u30a4\u30eb\u30b9\u53cd\u5fdc\u3084\u81ea\u5df1\u4fee\u5fa9\u306e\u305f\u3081\u306e\u5fdc\u7b54\u3082
\u3044\u304f\u3064\u304b\u306e\u7d4c\u8def\u3092\u7d4c\u3066\u59cb\u307e\u308a\u307e\u3059\u3002
\u305f\u3068\u3048\u3070\u3001TLR\uff19\u304c\u7570\u6240\u6027DNA\u3092\u8a8d\u8b58\u3057\u305f\u5834\u5408\u3001
MyD88\uff08myeloid differentiation factor 88\uff09\u3068\u547c\u3070\u308c\u308b
\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u4f9d\u5b58\u6027\u306b\u4e0b\u6d41\u306e\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3057\u3001
NF-\u03baB\uff08nuclear factor kappa B\uff09\u3084IRF7\uff08interferon regulatory factor 7\uff09
\u3068\u3044\u3063\u305f\u8ee2\u5199\u56e0\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001
\u6700\u7d42\u7684\u306bIL-6\u3084TNF\uff08tumor necrosis factor\uff09\u306a\u3069\u306e
\u5404\u7a2e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084I\u578bINF\u304c\u7523\u751f\u3055\u308c\u308b\u69d8\u306b\u306a\u308a\u307e\u3059\u3002
\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001AIM2\u69d8\u53d7\u5bb9\u4f53\u3084NLRP3\u306b\u3088\u308b\u8a8d\u8b58\u306e\u5834\u5408\u306f\u3001
ASC\uff08apoptosis-asociated specklike protein containing a CARD\uff09
\u3068\u3044\u3046\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u304c
\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3067\u3042\u308b\u30ab\u30b9\u30d1\u30fc\u30bc1\u524d\u99c6\u4f53\u3068\u3068\u3082\u306b
\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5185\u514d\u75ab\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3001
\u30ab\u30b9\u30d1\u30fc\u30bc1\u304c\u6d3b\u6027\u5316\u3055\u308c\u305f\u7d50\u679c\u3001
IL-1\u03b2\u3084IL-18\u304c\u7d30\u80de\u5916\u306b\u653e\u51fa\u3055\u308c\u308b\u3068\u3068\u3082\u306b\u3001
\u7d30\u80de\u81ea\u4f53\u306f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u6b7b\u3092\u8fce\u3048\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002
\u307e\u305f\u3001\uff43GAS\u306b\u3088\u3063\u3066\u7570\u6240\u6027DNA\u304c\u8a8d\u8b58\u3055\u308c\u305f\u5834\u5408\u3001
\u7d30\u80de\u8cea\u5185\u3067ATP\u304a\u3088\u3073GTP\u304b\u3089cGAMP\u3068\u547c\u3070\u308c\u308b
\u30bb\u30ab\u30f3\u30c9\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002
\u3053\u306ecGAMP\u306f\u5c0f\u80de\u4f53\u5185\u306b\u5c40\u5728\u3059\u308bSTING\uff08simulator of interferon gene\uff09
\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3057\u3001
NF-\u03baB\u3084IRF3\u3092\u4ecb\u3057\u3066I\u578bINF\u304c\u7523\u751f\u3055\u308c\u305f\u308a\u3057\u3066\u3001
\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u306e\u6025\u901f\u306a\u4f1d\u642c\u3068\u708e\u75c7\u53cd\u5fdc\u306e\u304c\u4fc3\u9032\u3055\u308c\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002
\u3053\u306e\uff43GAS\u21d2\uff43GAMP\u21d2STING\u7d50\u5408\u306e\u30eb\u30fc\u30c8\u3092
\uff43GAS\uff0dSTING\u7d4c\u8def\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n\n\n\n
\u3053\u306e\u30d6\u30ed\u30b0\u306f\u50d5\u306e\u5099\u5fd8\u9332\u3082\u517c\u306d\u3066\u3044\u308b\u306e\u3067
\u96d1\u8a8c\u3092\u8aad\u307f\u306a\u304c\u3089\u66f8\u3044\u3066\u307f\u307e\u3057\u305f\u304c\u3001
\u4f55\u304c\u4f55\u3060\u304b\u3054\u3061\u3083\u3054\u3061\u3083\u306b\u306a\u3063\u3066\u3057\u3044\u307e\u3057\u305f\u306d\u3002
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u524d\u56de\u306f\u3001\u5916\u304b\u3089\u3084\u3063\u3066\u304d\u305fRNA\u3084\u7d30\u80de\u306e\u4e2d\u3067\u8981\u3089\u306a\u304f\u306a\u3063\u305fRNA\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u8a8d\u8b58\u3055\u308c\u308b\u304b\u3092\u4e2d\u5fc3\u306b\u304a\u8a71\u3057\u307e\u3057\u305f\u3002 \u3067\u306fDNA\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f\u7570\u6240\u6027DNA\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3068\u3057\u3066\u306f\u3001\u3082\u3061\u308d\u3093\u611f\u67d3\u306b\u3088\u3063\u3066\u5fae\u751f\u7269\u304b\u3089\u3082\u305f\u3089\u3055\u308c\u308b …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[92],"class_list":["post-8405","post","type-post","status-publish","format-standard","hentry","category-blog","tag-92"],"_links":{"self":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/8405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8405"}],"version-history":[{"count":3,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/8405\/revisions"}],"predecessor-version":[{"id":8411,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/8405\/revisions\/8411"}],"wp:attachment":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}