{"id":8356,"date":"2022-05-01T08:28:00","date_gmt":"2022-04-30T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=8356"},"modified":"2022-05-08T22:42:46","modified_gmt":"2022-05-08T13:42:46","slug":"covid-19%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e8%ab%96%e6%96%87%e3%83%bb%e8%a8%98%e4%ba%8b%ef%bc%91","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=8356","title":{"rendered":"COVID-19\u306b\u95a2\u3059\u308b\u8ad6\u6587\u30fb\u8a18\u4e8b\uff11"},"content":{"rendered":"\n

\u3067\u304d\u308c\u3070\u4f53\u7cfb\u7684\u306b\u304a\u8a71\u3067\u304d\u306a\u3044\u304b\u306a\u3068\u601d\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001
\u30d0\u30bf\u30d0\u30bf\u3057\u3066\u3044\u308b\u9593\u306b\u6708\u65e5\u304c\u305f\u3063\u3066\u884c\u304f\u306e\u3067\u3001
\u3068\u308a\u3042\u3048\u305a\u76ee\u306b\u3064\u3044\u305f\u8ad6\u6587\u3084\u8a18\u4e8b\u3092\u4e0a\u3052\u3066\u3044\u304d\u307e\u3059\u3002

\u7ffb\u8a33\u30bd\u30d5\u30c8\u3092\u4f7f\u3063\u3066\u8aad\u3093\u3067\u307e\u3059\u306e\u3067\u3001
\u8aad\u307f\u9593\u9055\u3048\u3066\u3044\u308b\u90e8\u5206\u3082\u3042\u308b\u304b\u3068\u601d\u3044\u307e\u3059\u3002
\u8208\u5473\u3092\u6301\u305f\u308c\u305f\u65b9\u306f\u539f\u6587\u3092\u304a\u8aad\u307f\u304f\u3060\u3055\u3044\u3002

\u307e\u305a\u306f\u3053\u308c\uff1a
\u201dGut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome\uff08post-acute COVID-19 syndrome\u60a3\u8005\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u52d5\u614b\u306b\u3064\u3044\u3066\uff09\u201d
\u51fa\u5178\u306fBMJ journals Volume 71, Issue 3
http:\/\/dx.doi.org\/10.1136\/gutjnl-2021-325989<\/a>
\u9999\u6e2f\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002OpenAccess\u3067\u3059\u3002

\u63b2\u8f09\u306f\u4eca\u5e74\u306e\uff11\u6708\u3067\u3059\u304c\u3001\u6295\u7a3f\u306f\u6628\u5e74\u306e\uff18\u6708\u306e\u69d8\u3067\u3059\u3002
\u3067\u306e\u3059\u3067\u3001Omicron\u682a\u304c\u8513\u5ef6\u3059\u308b\u4ee5\u524d\u3068\u8003\u3048\u3066\u304a\u304f\u5fc5\u8981\u306f\u3042\u308a\u307e\u3059\u3002

post-acute COVID-19 syndrome\uff08PACS\uff09\u3068\u3044\u3046\u306e\u306f
\u3044\u308f\u3086\u308bLong-COVID\uff08\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u5f8c\u907a\u75c7\uff09\u3067\u3059\u3002

\u305d\u306e\u75c7\u72b6\u3068\u3057\u3066\u306f\u3001\uff16\u30ab\u6708\u6642\u70b9\u3067\u6700\u3082\u591a\u304b\u3063\u305f\u75c7\u72b6\u306f\u3001
\u75b2\u52b4\uff0831.3%\uff09\u3001\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b\uff0828.3%\uff09\u3001\u8131\u6bdb\uff0821.7%\uff09\u3001
\u4e0d\u5b89\uff0820.8%\uff09\u304a\u3088\u3073\u7761\u7720\u56f0\u96e3\uff0820.8%\uff09\u3060\u305d\u3046\u3067\u3059\u3002

\u4eca\u56de\u306e\u5831\u544a\u306f\u3001COVID-19\u306b\u7f79\u308a\u5165\u9662\u3057\u305f\u60a3\u8005\u3055\u3093\u306b\u95a2\u3057\u3066\u3001
\u5b8c\u6cbb\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3068PACS\u306b\u306a\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u306b\u3064\u3044\u3066\u3001
\u8178\u5185\u7d30\u83cc\u53e2\u304c\u3001\u5165\u9662\u6642\u3068\uff16\u30b1\u6708\u5f8c\u3067\u3069\u3046\u9055\u3046\u304b\u3092\u8abf\u3079\u305f\u3082\u306e\u3067\u3059\u3002

\u7d50\u679c\u3092\u5927\u96d1\u628a\u306b\u8a00\u3046\u3068\u3001
COVID-19\u306b\u306a\u3063\u305f\u4eba\u3068\u306a\u3063\u3066\u3044\u306a\u3044\u4eba\uff08\u5bfe\u7167\u7fa4\uff09\u3067\u306f
\u5165\u9662\u6642\u306e\u8178\u5185\u7d30\u83cc\u53e2\u306e\u7d44\u6210\u306f\u3001\u660e\u3089\u304b\u306b\u9055\u3063\u305f\u305d\u3046\u3067\u3059\u3002
\u7d30\u83cc\u53e2\u306e\u591a\u69d8\u6027\u304c\u6e1b\u3063\u3066\u8c4a\u5bcc\u3055\u3082\u6e1b\u5c11\u3057\u3066\u3044\u305f\u3068\u306e\u3053\u3068\u3002
\uff08\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u306e\u6709\u7121\u306f\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\uff09

\u305d\u3057\u3066\u3001\uff16\u30b1\u6708\u7d4c\u904e\u3057\u3066\u6cbb\u7652\u3057\u305f\u4eba\u3068PACS\u306b\u306a\u3063\u305f\u30d2\u30c8\u3067\u306f
\u6cbb\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u306f\u8178\u5185\u7d30\u83cc\u53e2\u306e\u7d44\u6210\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u8fd1\u3065\u304d\u307e\u3057\u305f\u304c\u3001
PACS\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u307e\u3060\u9055\u3044\u304c\u6b8b\u3063\u3066\u3044\u305f\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002
\"\"
\u30b0\u30e9\u30d5\u306f\u30b0\u30eb\u30fc\u30d7\u306e\u985e\u4f3c\u6027\u3092\u6bd4\u3079\u3066\u3044\u307e\u3059\u3002
\u5bfe\u7167\u7fa4\uff08\u30b0\u30ec\u30fc\uff09\u3068\u6bd4\u3079\u3066\u3001PACS\u306b\u306a\u3063\u305f\u7fa4\u306e\u5165\u9662\u6642\uff08\u30aa\u30ec\u30f3\u30b8\uff09\u306f
\u304b\u306a\u308a\u96e2\u308c\u3066\u3044\u307e\u3059\uff08\u30b0\u30ec\u30fc\u3068\u306f\u4f3c\u3066\u3044\u306a\u3044\uff09\u3002
PACS\u306b\u306a\u3089\u305a\u306b\u6700\u7d42\u7684\u306b\u6cbb\u3063\u305f\u30b0\u30eb\u30fc\u30d7\uff08\u9752\uff09\u306f
\u30aa\u30ec\u30f3\u30b8\u307b\u3069\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u305d\u308c\u3067\u3082\u30b0\u30ec\u30fc\u3068\u306f\u5c11\u3057\u9055\u3063\u3066\u3044\u307e\u3059\u3002
\uff16\u30b1\u6708\u5f8cPACS\u306b\u306a\u3089\u306a\u304b\u3063\u305f\u7fa4\u306f\u304b\u306a\u308a\u5bfe\u7167\u7fa4\u306b\u8fd1\u3065\u304d\u307e\u3057\u305f\uff08\u6c34\u8272\uff09\u304c\u3001
PACS\u306b\u306a\u3063\u305f\u7fa4\u306f\u307e\u3060\u8178\u5185\u7d30\u83cc\u53e2\u306e\u7d44\u6210\u304c\u5bfe\u7167\u7fa4\u3068\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002

\u3067\u306f\u3001\u3053\u3053\u3067\u3069\u3093\u306a\u7d30\u83cc\u304c\u3069\u3046\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304b\u3002
\u8457\u8005\u3089\u306f\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5c11\u306a\u304f\u7814\u7a76\u306e\u9650\u754c\u3068\u524d\u7f6e\u304d\u3057\u306a\u304c\u3089\u3082
\u3044\u308d\u3044\u308d\u3068\u8003\u5bdf\u3057\u3066\u3044\u307e\u3059\u3002

\uff16\u30b1\u6708\u5f8c\u300173.5\uff05\u304cPACS\u306b\u306a\u3063\u305f\u305d\u3046\u3067\u3059\u304c\u3001
\u767a\u75c7\u6642\u306e\u30a6\u30a4\u30eb\u30b9\u91cf\u3068PACS\u767a\u75c7\u306b\u512a\u4f4d\u306a\u95a2\u9023\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3002

\u7d30\u83cc\u304c\u3069\u3046\u9055\u3063\u305f\u304b\uff1a
\"\"
PACS\u60a3\u8005\u306f\u975eCOVID-19\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001
Collinsella aerofaciens, F. prausnitzii, Blautia obeum
\uff08\u4e0a\u306e\u30b0\u30e9\u30d5\u30aa\u30ec\u30f3\u30b8\u4e0b\u304b\u30891,2,4\uff09\u304c\u6709\u610f\u306b\u5c11\u306a\u304f\u3001
Ruminococcus gnavus\u3068Bacteroides vulgatus\uff08\u9752\u8272\u306e\u4e0a\u306e\uff12\u3064\uff09\u304c
\u591a\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002

Collinsella\u306b\u3064\u3044\u3066\u306f\u4ee5\u524d\u306e\u5f53\u9662\u306e\u30d6\u30ed\u30b0\u3067\u3082
\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002
\uff1eSARS-Cov-2\u3068\u8178\u5185\u7d30\u83cc\uff12<\/a>\u3000
\u3084\u3063\u3071\u308aCollinsella\u304c\u8178\u5185\u306b\u3044\u308b\u65b9\u304c\u3088\u3055\u305d\u3046\u3067\u3059\u3002

\u6b21\u306bPACS\u306e\u75c7\u72b6\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u9023\u3092\u8abf\u3079\u307e\u3057\u305f\u3002
\u547c\u5438\u5668\u75c7\u72b6\u304c\u6301\u7d9a\u3059\u308b\u60a3\u8005\u306e\u8178\u5185\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u69cb\u6210\u306f\u3001
Streptococcus anginosus\u3001Streptococcus vestibularis\u3001
Streptococcus gordonii\u3001Clostridium disporicum\u306a\u3069\u306e
\u591a\u304f\u306e\u65e5\u548c\u898b\u75c5\u539f\u4f53\u3068\u6b63\u306e\u76f8\u95a2\u304c\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002
\u3053\u308c\u3089\u306e\u7d30\u83cc\u304c\u591a\u3044\u3068\u547c\u5438\u5668\u75c7\u72b6\u304c\u6301\u7d9a\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001
\u547c\u5438\u5668\u75c7\u72b6\u304c\u7d9a\u304f\u305f\u3081\u306b\u3053\u308c\u3089\u306e\u7d30\u83cc\u304c\u5897\u3048\u305f\u53ef\u80fd\u6027\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002

\u540c\u69d8\u306b\u3001\u795e\u7d4c\u7cbe\u795e\u75c7\u72b6\u304a\u3088\u3073\u75b2\u52b4\u3068\u3044\u3063\u305f\u75c7\u72b6\u306f\u3001
Clostridium innocuum\u3001Actinomyces naeslundii\u306a\u3069\u3068\u76f8\u95a2\u304c\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002

\u3055\u3089\u306b\u3001Faecalibacterium prausnitzii\u306a\u3069\u306e\u916a\u9178\u7523\u751f\u7a2e\u306f\u3001
6\u30ab\u6708\u5f8c\u306b\u8131\u6bdb\u304c\u6301\u7d9a\u3057\u3066\u3044\u308b\u60a3\u8005\uff08n=23\uff09\u3067\u306f\u3001
COVID-19\u4ee5\u5916\u306e\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u305f\u305d\u3046\u3067\u3059\u3002

\u7dcf\u62ec\u3068\u3057\u3066\u3001Bifidobacteria\u5c5e\u3001Roseburia\u5c5e\u3001Faecalibacteria\u5c5e\u3092\u542b\u3080
\u3044\u304f\u3064\u304b\u306e\u5171\u751f\u7d30\u83cc\u306e\u640d\u5931\u304c\u3001\u7279\u306b\u75c7\u72b6\u306e\u6301\u7d9a\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u305d\u3046\u3067\u3059\u3002
\u7279\u306b\u6700\u5f8c\u306e2\u3064\u306e\u7d30\u83cc\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u77ed\u9396\u8102\u80aa\u9178\u3092\u7523\u751f\u3059\u308b\u91cd\u8981\u306a\u7d30\u83cc\u3067\u3042\u308a\u3001
\u514d\u75ab\u6052\u5e38\u6027\u306e\u7dad\u6301\u306b\u4e3b\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002

\u305f\u3068\u3048\u3070\u3001F. prausnitzii \u306f\u3001\u514d\u75ab\u8abf\u7bc0\u7279\u6027\u3092\u6301\u3061\u3001
NF-kB \u7d4c\u8def\u306e\u963b\u5bb3\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u306e\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f324\u3001
\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3 8 \u306e\u5408\u6210\u3084\u5206\u6ccc\u306e\u6291\u5236\u306a\u3069
\u5bbf\u4e3b\u9632\u5fa1\u306b\u8ca2\u732e\u3067\u304d\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002

\u6700\u7d42\u7684\u306b\u306f\u3001\u3082\u3063\u3068\u5927\u898f\u6a21\u306a\u8abf\u67fb\u304c\u306a\u3055\u308c\u3066\u307f\u306a\u3044\u3068\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001
\u4eca\u5f8c\u8178\u5185\u7d30\u83cc\u53e2\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001PACS\u3092\u4e88\u9632\u3057\u305f\u308a\u6cbb\u7642\u3057\u305f\u308a\u3067\u304d\u308b\u3088\u3046\u306b
\u306a\u3063\u3066\u3044\u304f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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