{"id":7667,"date":"2021-04-19T22:54:35","date_gmt":"2021-04-19T13:54:35","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=7667"},"modified":"2022-04-21T22:46:36","modified_gmt":"2022-04-21T13:46:36","slug":"sars-cov-2%e3%81%a8%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95%e3%82%a7%e3%83%ad%e3%83%b32","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=7667","title":{"rendered":"SARS-Cov-2\u3068\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f32"},"content":{"rendered":"\n

\u6628\u65e5\u304b\u3089\u3072\u304d\u7d9a\u304d\u3001
\u201dThe dual nature of type-I interferons in SARS-CoV-2 induced inflammation<\/a>\uff08SARS-CoV-2\u8a98\u767a\u6027\u708e\u75c7\u306b\u304a\u3051\u308bI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u4e8c\u91cd\u306e\u6027\u8cea\uff09\u201d
\u3068\u3044\u3046\u8ad6\u6587\u3092\u8aad\u3093\u3067\u3044\u304d\u307e\u3059\u3002

SARS-Cov-2\u306f\u76e3\u8996\u306e\u76ee\u3092\u304f\u3050\u308a\u3001INF\u306e\u7523\u751f\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3067\u3001
\u5897\u6b96\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002

\u3055\u3089\u306b\u56f0\u3063\u305f\u3053\u3068\u306b\u3001\u6700\u8fd1\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001
\u4eca\u5ea6\u306f\u5bbf\u4e3b\uff08\u3064\u307e\u308a\u79c1\u305f\u3061\uff09\u306e\u4e2d\u306b
INF-I\u3092\u4e2d\u548c\u3055\u305b\u3066\u3057\u307e\u3046\u81ea\u5df1\u6297\u4f53\u3068\u3044\u3046\u306e\u3092
\u6301\u3063\u3066\u3044\u308b\u4eba\u304c\u4e00\u5b9a\u306e\u5272\u5408\u3067\u3044\u308b\u69d8\u306a\u306e\u3067\u3059\u3002

\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u91cd\u75c7\u306eCOVID-19\u60a3\u8005\u306e10.2\uff05\u306b
\u81ea\u5206\u306eINF\u3092\u7121\u529b\u306b\u3057\u3066\u3057\u307e\u3046\u6297\u4f53\u304c\u5b58\u5728\u3057\u3066\u3044\u305f\u305d\u3046\u3067\u3059\u3002

\u305f\u3060\u3057\u3001\u3053\u3046\u3057\u305fINF\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u3082\u3063\u305f\u60a3\u8005\u3055\u3093\u306f\u3001
\u3044\u305a\u308c\u3082\u904e\u53bb\u306b\u5165\u9662\u3092\u5fc5\u8981\u3068\u3059\u308b\u3088\u3046\u306a\u3001
\u751f\u547d\u3092\u8105\u304b\u3059\u3088\u3046\u306a\u30a6\u30a4\u30eb\u30b9\u6027\u75be\u60a3\u306e\u75c5\u6b74\u304c\u3042\u3063\u305f\u69d8\u3067\u3001
\u3053\u308c\u306f\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u3068\u3057\u3066\u77e5\u3063\u3066\u304a\u304f\u3079\u304d\u3053\u3068\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002

\u4e00\u822c\u7684\u306b\u3001\u30ef\u30af\u30c1\u30f3\u3092\u3046\u3064\u610f\u5473\u3068\u3044\u3046\u306e\u306f\u3001
SARS-Cov-2\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u4f5c\u308b\u305f\u3081
\u3068\u7406\u89e3\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u3002
\u3053\u306e\u305f\u3081\u3053\u308c\u307e\u3067\u306eCOVID-19\u306e\u7814\u7a76\u306f\u3001
SARS-Cov-2\u7279\u7570\u7684\u6297\u4f53\u306eB\u7d30\u80de\u7523\u751f\u306b
\u7126\u70b9\u3092\u5408\u308f\u305b\u3066\u304d\u3066\u3044\u307e\u3059\u3002

\u3057\u304b\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3057\u3066\u3057\u307e\u3046\u3068\u3001
\u6297\u4f53\u306f\u5168\u304f\u5f79\u306b\u305f\u305f\u306a\u3044\u3053\u3068\u3092\u5fd8\u308c\u304c\u3061\u3060\u3068\u7b46\u8005\u306f\u8a00\u3044\u307e\u3059\u3002
\uff08\u307e\u3042\u3001\u7d30\u80de\u5185\u3067\u5897\u6b96\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u304c\u8840\u4e2d\u306b\u51fa\u3066\u304d\u305f\u3068\u3053\u308d\u3092
\u3000\u53e9\u3051\u3070\u7d50\u679c\u7684\u306b\u306fOK\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001
\u3000\u7d50\u5c40\u305d\u308c\u3067\u306f\u3001\u611f\u67d3\u7d30\u80de\u304b\u3089\u6b21\u3005\u3068\u30a6\u30a4\u30eb\u30b9\u304c
\u3000\u4f9b\u7d66\u3055\u308c\u308b\u3067\u3057\u3087\u3046\u304b\u3089\u3001\u6700\u7d42\u7684\u306b\u306f\u75b2\u5f0a\u3057\u3066\u8ca0\u3051\u304b\u3082\u3002\uff09

\u305d\u308c\u306f\u3068\u3082\u304b\u304f\u3001\u3082\u3057\u3001\u7d30\u80de\u304c\u611f\u67d3\u3057\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306f\u3001
T\u7d30\u80de\u3001\u7279\u306bCD8+\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\uff08CTL\uff09\u304c\u3001
\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u306e\u6392\u9664\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u306e\u3067\u3001
T\u7d30\u80de\u304c\u5143\u6c17\u3067\u3042\u308b\u3053\u3068\u3082\u5927\u5207\u3067\u3059\u3002

\u4e00\u65b9\u3001CD4+T\u7d30\u80de\u306f\u3001\u6628\u65e5\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u3001
INF-I\u3068IL-15\u306e\u523a\u6fc0\u306b\u3088\u3063\u3066\u6ffe\u80de\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08Tfh\uff09\u306b\u5909\u5316\u3057\u3001
Tfh\u306fB\u7d30\u80de\u3068\u5354\u540c\u3057\u3066\u6297\u4f53\u7523\u751f\u3092\u884c\u3046\u3053\u3068\u304b\u3089\u3001
\u3053\u3061\u3089\u3082T\u7d30\u80de\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002

\u3053\u306eTfh\u3068B\u7d30\u80de\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001
\u30ea\u30f3\u30d1\u7bc0\u306e\u80da\u4e2d\u5fc3\u3068\u547c\u3070\u308c\u308b\u3068\u3053\u308d\u3067\u884c\u308f\u308c\u3044\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u304c\u3001
\u91cd\u5ea6\u306eCOVID-19\u60a3\u8005\u3067\u306f\u3001
\u3053\u306e\u80da\u4e2d\u5fc3\u304c\u9855\u8457\u306a\u6a5f\u80fd\u969c\u5bb3\u306b\u9665\u3063\u3066\u3044\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002

CD4+T\u7d30\u80de\u3092\u3053\u306eTfh\u306b\u5206\u5316\u3055\u305b\u308b\u306e\u306b
INF-I\u304c\u91cd\u8981\u306a\u306e\u3067\u3059\u304c\u3001
\u3053\u3053\u3067\u300c\u8001\u5316\u300d\u306e\u554f\u984c\u304c\u51fa\u3066\u304d\u307e\u3059\u3002
\u514d\u75ab\u8001\u5316\u306e\u539f\u56e0\u306f\u8b70\u8ad6\u306e\u4f59\u5730\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u304c\u3001
\u8001\u5316\u81ea\u4f53\u304cIFN-1\u6a5f\u80fd\u4e0d\u5168\u306b\u95a2\u9023\u3057\u3066\u3044\u308b
\u3068\u3044\u3046\u8a3c\u62e0\u304c\u5897\u3048\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002

\u5b9f\u969b\u3001 \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306a\u3069\u306e\u4ed6\u306e\u30a6\u30a4\u30eb\u30b9\u3067\u306e\u5fdc\u7b54\u306f\u3001
\u8001\u5316\u306b\u3088\u308aINF-I\u304a\u3088\u3073INF-III\u7523\u751f\u304c
\u6025\u901f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002
\u3053\u308c\u306fSARS-Cov-2\u611f\u67d3\u3067\u3082\u540c\u69d8\u3067\u3059\u3002\u3002
\u3064\u307e\u308a\u3001COVID-19\u306e\u91cd\u75c7\u5316\u306f\u3001
\u4e3b\u306b\u514d\u75ab\u8001\u5316\u306b\u3088\u308bIFN-I\u6a5f\u80fd\u4e0d\u5168\u306e\u53cd\u6620\u306a\u3093\u3060\u3068\u3002
\uff08\u307e\u3001\u305d\u308c\u3060\u3051\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304c\uff09

\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306e\u52b9\u679c\u7684\u306a\u514d\u75ab\u5fdc\u7b54\u306f\u3001
\u611f\u67d3\u521d\u671f\u306bINF-I\u304cT\u7d30\u80de\u3068\u63a5\u89e6\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3001
\u3053\u306e\u63a5\u89e6\u304c\u306a\u3044\u3068\u3001\u75be\u60a3\u306f\u91cd\u7be4\u306b\u306a\u308a\u307e\u3059\u3002
\u305d\u3053\u3067\u611f\u67d3\u521d\u671f\u306bINF-I\uff08\u307e\u305f\u306f\u305d\u306e\u8a98\u5c0e\u4f53\uff09\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001
\u75be\u60a3\u306e\u91cd\u75c7\u5316\u304c\u4e88\u9632\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001
\u554f\u984c\u306a\u306e\u306f\u3001\u6bb5\u968e\u304c\u9032\u3093\u3067\u3057\u307e\u3046\u3068\u4e88\u9632\u3067\u304d\u306a\u3044\u3001
\u305d\u308c\u3069\u3053\u308d\u304bSARS-Cov-2\u306e\u5834\u5408\u3001
\u3080\u3057\u308d\u60aa\u5316\u3092\u5c0e\u3044\u3066\u3057\u307e\u3046\u306e\u3060\u305d\u3046\u3067\u3059\u3002
\u3064\u307e\u308a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u3092\u5f15\u304d\u8d77\u3053\u3059\u308f\u3051\u3067\u3059\u3002

\u3067\u3059\u304b\u3089INF\u306f\u611f\u67d3\u306e\u521d\u671f\u306b\u3053\u305d\u6295\u4e0e\u3059\u308b\u3079\u304d\u3082\u306e\u3067\u3001
\u5f8c\u671f\u306b\u6295\u4e0e\u306f\u9006\u52b9\u679c\u306b\u306a\u308b\u305d\u3046\u3067\u3059\u3002

COVID-19\u306b\u5bfe\u3057\u3066INF-I\u306e\u6295\u4e0e\u306f\u3001
\u6295\u4e0e\u3059\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u91cd\u8981\u3068\u8a00\u3046\u3053\u3068\u3067\u3059\u306d\u3002

********
SARS-Cov-2\u306b\u5bfe\u3059\u308bINF\u306b\u3064\u3044\u3066
\u4ed6\u306b\u3082\u3053\u3093\u306a\u8a18\u4e8b\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002

\uff1e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3068\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306b\u3064\u3044\u3066<\/a>

\u65e5\u672cRNA\u5b66\u4f1a\u3068\u3044\u3046\u306e\u304c\u3042\u308b\u3093\u3067\u3059\u306d\u3002
\u3053\u3061\u3089\u306b\u30ea\u30ec\u30fc\u30a8\u30c3\u30bb\u30fc\u304c\u3042\u308a\u3001\u305d\u306e\u4e2d\u3067\u4eca\u56de\u306eCOVID-19\u3068
INF\u306b\u3064\u3044\u3066\u5c02\u9580\u5bb6\u306e\u5148\u751f\u306e\u304a\u8a71\u3092\u8aad\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002

\u3053\u3053\u306bINF\u304cCOVID-19\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u306b\u5bfe\u3059\u308b
\u8003\u5bdf\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002

SARS-Cov-2\u30a6\u30a4\u30eb\u30b9\u304c\u4eba\u4f53\u306b\u611f\u67d3\u3059\u308b\u5834\u5408\u3001
ACE2\u3068\u3044\u3046\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u6a19\u7684\u306b\u3057\u3066\u80ba\u306a\u3069\u3067\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3001
\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u3059\u3067\u306b\u3044\u308d\u3093\u306a\u3068\u3053\u308d\u3067\u8aad\u307f\u307e\u3057\u305f\u3002

\u3068\u3053\u308d\u304c\u6700\u8fd1\u3001
ACE2\u306fI\u578bIFN\u306b\u3088\u3063\u3066\u767a\u73fe\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u306e\u3060\u3068\u3002
\u3082\u3057I\u578bIFN\u306e\u6295\u4e0e\u91cf\u304c\u4f4e\u3059\u304e\u308b\u3068\u3001I\u578bIFN\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u4f5c\u7528\u3088\u308a\u3082\u3001
ACE2\u306e\u767a\u73fe\u4e0a\u6607\u3092\u4ecb\u3057\u305f\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u4f1d\u642c\u306e\u65b9\u304c
\u4e0a\u56de\u308b\u53ef\u80fd\u6027\u304c\u51fa\u3066\u304f\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002

\u3064\u307e\u308a\u3001\u6295\u4e0e\u91cf\u304c\u6700\u9069\u3067\u306a\u3044\u3068\u3001
I\u578bIFN\u306b\u3088\u3063\u3066\u6cbb\u7642\u3092\u3057\u3066\u3044\u308b\u306f\u305a\u304c\u3001
\u304b\u3048\u3063\u3066\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3092\u80ba\u7d44\u7e54\u306b\u5e83\u3081\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3002
\u3053\u308c\u306f\u5927\u5909\u306a\u3053\u3068\u3067\u3059\u3002

SARS-Cov-2\u306f\u3082\u3068\u3082\u3068INF\u304b\u3089\u8a98\u5c0e\u3055\u308c\u308b\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3092
\u56de\u907f\u3055\u305b\u308b\u8853\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3001
INF-I\u3092COVID-19\u306e\u6cbb\u7642\u306b\u7528\u3044\u308b\u5834\u5408\u3001
\u4ed6\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u6cbb\u7642\u6642\u3068\u6bd4\u3079\u3001
\u5927\u91cf\u306b\u6295\u4e0e\u3057\u306a\u3044\u3068\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u305d\u3046\u3067\u3059\u3002

\u305d\u3046\u3059\u308b\u3068\u3001\u3055\u3089\u306b\u305d\u3053\u306b\u554f\u984c\u304c\u767a\u751f\u30fb\u30fb\u30fb
I\u578bIFN\u306e\u91cd\u5927\u306a\u526f\u4f5c\u7528\u306e\u4e2d\u306b\u3001
\u983b\u5ea6\u306f\u4f4e\u3044\u304c\u9593\u8cea\u6027\u80ba\u708e\u304c\u3042\u308b\u305d\u3046\u3067\u3001
\u305f\u3060\u3067\u3055\u3048COVID-19\u306f\u80ba\u306b\u640d\u50b7\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u4e0a\u306b\u3001
\u9593\u8cea\u6027\u80ba\u708e\u306b\u79fb\u884c\u3057\u3084\u3059\u3044\u3068\u3059\u308c\u3070\u3001
\u305d\u306e\u81e8\u5e8a\u5fdc\u7528\u306f\u3001\u7c21\u5358\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002

\u3046\u30fc\u3093\u3001\u30b6\u30f3\u30cd\u30f3\uff01

\u307e\u3042\u3001\u78ba\u304b\u306b\u3001\u305d\u308c\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3063\u3066\u3001
C\u578b\u809d\u708e\u306e\u6cbb\u7642\u3067\u7528\u3044\u3089\u308c\u307e\u3059\u304c\u3001
\u521d\u671f\u306e\u526f\u4f5c\u7528\u306b\u767a\u71b1\u3084\u5168\u8eab\u5026\u6020\u611f\u3001\u7b4b\u8089\u75db\u306a\u3069\u3082\u3042\u308b\u305d\u3046\u3067\u3001
\u6ce8\u5c04\u3068\u70b9\u9f3b\u306e\u9055\u3044\u306f\u3042\u3063\u3066\u3082\u3001
\u3053\u308c\u3058\u3083\u3041\u3001SARS-Cov-2\u306b\u611f\u67d3\u3057\u305f\u304b\u3082\u3068\u8a00\u3046\u3068\u304d\u306b\u4f7f\u3063\u305f\u3089\u3001
COVID-19\u3092\u767a\u75c7\u3057\u305f\u306e\u304bINF\u306e\u526f\u4f5c\u7528\u306a\u306e\u304b\u3001
\u533a\u5225\u304c\u3064\u304b\u306a\u304f\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002

\u4e2d\u3005\u3046\u307e\u304f\u884c\u304d\u307e\u305b\u3093\u306d\u3002


<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6628\u65e5\u304b\u3089\u3072\u304d\u7d9a\u304d\u3001\u201dThe dual nature of type-I interferons in SARS-CoV-2 induced inflammation\uff08SARS-CoV-2\u8a98\u767a\u6027\u708e\u75c7\u306b\u304a\u3051\u308bI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7 …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89,6],"tags":[67],"class_list":["post-7667","post","type-post","status-publish","format-standard","hentry","category-covid-19","category-blog","tag-covid-19"],"_links":{"self":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/7667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7667"}],"version-history":[{"count":2,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/7667\/revisions"}],"predecessor-version":[{"id":7669,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/7667\/revisions\/7669"}],"wp:attachment":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}