{"id":7512,"date":"2021-02-10T08:28:41","date_gmt":"2021-02-09T23:28:41","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=7512"},"modified":"2022-04-21T22:47:16","modified_gmt":"2022-04-21T13:47:16","slug":"covid-19%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e8%a8%98%e4%ba%8b","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=7512","title":{"rendered":"COVID-19\u306b\u95a2\u3059\u308b\u8a18\u4e8b"},"content":{"rendered":"\n

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\u5fc3\u914d\u3057\u3059\u304e\u3066\u3082\u3044\u3051\u307e\u305b\u3093\u304c\u4fae\u3063\u3066\u3082\u3044\u3051\u307e\u305b\u3093\u3002

\u30c6\u30ec\u30d3\u306e\u60c5\u5831\u756a\u7d44\u306f\u3042\u307e\u308a\u898b\u306a\u3044\u69d8\u306b\u3057\u3066\u3044\u307e\u3059\u304c\u3001
\u30cd\u30c3\u30c8\u3067\u306f\u201dCOVID-19\u201d\u3068\u3044\u3046\u6587\u5b57\u304c\u76ee\u306b\u5165\u308b\u3068
\u3064\u3044\u3064\u3044\u898b\u3066\u3057\u307e\u3044\u307e\u3059\u3002
\u3068\u3044\u3046\u308f\u3051\u3067\u3001\u4eca\u56de\u3082\u3061\u3087\u3063\u3068\u3081\u306b\u3064\u3044\u305f\u8a18\u4e8b\u3092\u7d39\u4ecb\u3002

\u201dImmune determinants of COVID-19 disease presentation and severity\u201d
\uff08COVID-19\u75be\u60a3\u306e\u75c7\u72b6\u3068\u91cd\u75c7\u5ea6\u306e\u514d\u75ab\u6c7a\u5b9a\u56e0\u5b50\uff09
\u51fa\u5178\u306fNature Medicine volume 27,pages28-33(2021)<\/a>

COVID-19\u306f\u8efd\u75c7\uff5e\u91cd\u75c7\u307e\u3067\u632f\u308c\u5e45\u306e\u5e83\u3044\u75c5\u6c17\u3067\u3059\u304c\u3001
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\u307e\u305f\u3001\u55ab\u7159\u306f\u3055\u3089\u306b\u5225\u306e\u5371\u967a\u56e0\u5b50\u3067\u3059\u3002
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SARS-CoV-2\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u3001
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\u305f\u3060\u3001\u4eca\u56de\u306e\u8996\u70b9\u306f\u5225\u306e\u3068\u3053\u308d\u306b\u3042\u308a\u307e\u3059\u3002
\u3053\u3046\u3057\u305f\u6025\u6027\u671f\u306eCOVID-19\u306e\u91cd\u75c7\u5ea6\u3068\u306f\u5225\u306e\u554f\u984c\u70b9\u304c
1\u5e74\u3061\u3087\u3063\u3068\u7d4c\u904e\u3057\u3066\u304d\u3066\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002

\u305d\u308c\u306f\u3001COVID-19\u306e\u521d\u671f\u75c7\u72b6\u304c\u91cd\u75c7\u3067\u306a\u304b\u3063\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001
\u521d\u671f\u611f\u67d3\u5f8c\u4f55\u30f6\u6708\u3082\u306e\u9593\u3001
\u3055\u307e\u3056\u307e\u306a\u8870\u5f31\u6027\u306e\u75c7\u72b6\u306b\u82e6\u3057\u3080\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3002
\u3053\u306e\u72b6\u614b\u306f\u3001\u201dLong-COVID\u201d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002
\uff08\u30c6\u30ec\u30d3\u3067\u3082\u6700\u8fd1\u306f\u8a71\u984c\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u306d\uff09

\u6b63\u78ba\u306a\u5b9a\u7fa9\u306f\u306a\u3044\u69d8\u3067\u3059\u304c\u3001
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\u3053\u3046\u3057\u305f\u75c7\u72b6\u306f\u3001\u30a8\u30dc\u30e9\u51fa\u8840\u71b1\u3084
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\u30a6\u30a4\u30eb\u30b9\u6027\u75be\u60a3\u306e\u5f8c\u907a\u75c7\u3068\u985e\u4f3c\u3057\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002
\u307e\u305f\u3001\u81ea\u5f8b\u795e\u7d4c\u7cfb\u306e\u8abf\u7bc0\u4e0d\u5168\u306f
\u7b4b\u75db\u6027\u8133\u810a\u9ac4\u708e\u3068\u3082\u4f3c\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002

\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3082\u3046\u4e00\u3064\u3001
\u6025\u6027\u671f\u3088\u308a\u5c11\u3057\u9045\u308c\u3066\u751f\u3058\u308b\u5408\u4f75\u75c7\u3001
\u591a\u81d3\u5668\u708e\u75c7\u6027\u75c7\u5019\u7fa4\u306b\u3064\u3044\u3066\u3082\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002

SARS-Cov-2\u611f\u67d3\u5f8c2\uff5e6\u9031\u5f8c\u306b\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001
\u6700\u521d\u306f\u5c0f\u5150\u3067\u5831\u544a\u3055\u308c\u3001
Multisystem Inflammatory Syndrome in Children (MIS-C)
\u3068\u547c\u3070\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u5f8c\u82e5\u5e74\u8005\u3067\u3082\uff08MIS-A\uff09\u5831\u544a\u3055\u308c\u3066\u3044\u3066\u3001
\u305d\u306e\u75c5\u614b\u306f\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u3067\u5ddd\u5d0e\u75c5\u306b\u4f3c\u305f\u904e\u708e\u75c7\u75c7\u5019\u7fa4\u306a\u3093\u3060\u305d\u3046\u3067\u3059\u3002

\u3053\u306e\u8a18\u4e8b\u3067\u306f\u6700\u5f8c\u306b\u3001
COVID-19\u306e\u9ad8\u30ea\u30b9\u30af\u3068\u4f4e\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b
\u514d\u75ab\u5b66\u7684\u306a\u5dee\u7570\u306b\u3064\u3044\u3066\u8a00\u53ca\u3057\u3066\u3044\u307e\u3059\u3002

\u6027\u5dee\uff1a
\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u81ea\u7136\u514d\u75ab\u3067\u5fdc\u3058\u308b\u5834\u5408\u3001
I\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08INF-I\uff09\u3067\u5fdc\u7b54\u3057\u307e\u3059\u304c\u3001
\u305d\u306e\u5fdc\u7b54\u306f\u5973\u6027\u306e\u65b9\u304c\u5f37\u3044\u305d\u3046\u3067\u3059\u3002
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\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u4e00\u822c\u7684\u306a\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u3001
TLR7\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u3063\u3066\u3001\u3053\u308c\u306fX\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\u3089\u3057\u304f\u3001
\u305d\u308c\u304c\u6027\u5dee\u3068\u3057\u3066\u751f\u3058\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305d\u3046\u3067\u3059\u3002

\u307e\u305f\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u3084\u3063\u3064\u3051\u308bINF-I\u306b\u5bfe\u3057\u3066\u3001
\u3053\u308c\u3092\u4e2d\u548c\u3057\u3066\u3057\u307e\u3046\u81ea\u5df1\u6297\u4f53\u304c\u51fa\u6765\u3066\u3057\u307e\u3046\u5834\u5408\u304c\u3042\u3063\u3066\u3001
\u305d\u308c\u306f\u4f55\u6545\u304b\u306f\u4e0d\u660e\u3067\u3059\u304c\u7537\u6027\u306e\u65b9\u304c\u591a\u3044\u305d\u3046\u3067\u3059\u3002

\u306a\u304aMIS-C\u306b\u306f\u7537\u5973\u5dee\u306f\u306a\u304f\u3001
\u4e0a\u306b\u66f8\u304d\u307e\u3057\u305f\u304cLong-COVID\u306f\u5973\u6027\u306b\u591a\u3044\u69d8\u3067\u3059\u3002

\u5e74\u9f62\u5dee\uff1a
\u65b0\u751f\u5150\u3084\u5e7c\u5150\u306f\u4e00\u822c\u7684\u306b\u306fINF-I\u306e\u7523\u751f\u306f\u5c11\u306a\u3044\u3089\u3057\u304f\u3001
\u672c\u6765\u5e7c\u5150\u306f\u611f\u53d7\u6027\u304c\u9ad8\u3044\u306f\u305a\u306a\u3093\u3060\u305d\u3046\u3067\u3059\u3002
\u5b9f\u969b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306a\u3069\u306f\u5e7c\u5150\u3082\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u69d8\u306b\u601d\u3044\u307e\u3059\u3002
COVID-19\u3067\u5c0f\u5150\u304c\u91cd\u75c7\u5316\u3057\u306b\u304f\u3044\u306e\u306b\u306f\u3001
\u82e5\u8005\u3068\u9ad8\u9f62\u8005\u306e\u9593\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u72b6\u614b\u306e\u69cb\u6210\u7684\u306a\u9055\u3044\u304c
\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3002

\u5e7c\u5150\u3067\u306f\u30ea\u30f3\u30d1\u7403\u306e\u4e2d\u306e\u30d8\u30eb\u30d1\u30fc2T\u7d30\u80de\uff08TH2\uff09\u304c\u3001
\u30d8\u30eb\u30d1\u30fc1T\u7d30\u80de\uff08TH1\uff09\u3088\u308a\u3082\u591a\u3044\u306e\u306b\u5bfe\u3057\u3066\u3001
\u9ad8\u9f62\u8005\u3084\u80a5\u6e80\u3067\u306f\u3053\u306e\u6bd4\u7387\u304c\u9006\u8ee2\u3057
TH1\uff1eTH2\u306a\u3093\u3060\u305d\u3046\u3067\u3059\u3002

\"\"

NLR\uff1a
COVID-19\u306e\u91cd\u75c7\u5ea6\u306f\u3001\u767d\u8840\u7403\u4e2d\u306e\u6210\u5206\uff1a
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NLR\u6bd4\u306f\u7279\u306b\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u30842\u578b\u7cd6\u5c3f\u75c5\u3001
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NLR\u6bd4\u306f\u3001\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u3001\u300c\u708e\u75c7\u306b\u3088\u308b\u300c\u8001\u5316\uff08inflammaging\uff09\u300d\u3001
\u304a\u3088\u3073\u80a5\u6e80\u3068\u95a2\u9023\u304c\u3042\u308a\u3001
COVID-19\u306e\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50\u306a\u3093\u3060\u305d\u3046\u3067\u3059\u3002

\u3084\u305b\u306a\u304d\u3083\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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