{"id":7474,"date":"2021-01-20T08:28:00","date_gmt":"2021-01-19T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=7474"},"modified":"2022-04-21T22:47:58","modified_gmt":"2022-04-21T13:47:58","slug":"%e8%a3%9c%e4%b8%ad%e7%9b%8a%e6%b0%97%e6%b9%af%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=7474","title":{"rendered":"\u88dc\u4e2d\u76ca\u6c17\u6e6f\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u4f5c\u7528"},"content":{"rendered":"\n

\u65b0\u578b\u30b3\u30ed\u30ca\u611f\u67d3\u75c7\uff08COVID-19\uff09\u306e\u7b2c3\u6ce2\u306e\u53ce\u675f\u304c
\u307e\u3060\u307e\u3060\u898b\u3048\u307e\u305b\u3093\u304c\u3001\u4f55\u3068\u304b\u4e57\u308a\u5207\u3063\u3066\u3044\u304d\u305f\u3044\u3082\u306e\u3067\u3059\u3002

\u4eca\u56de\u306fCOVID-19\u306b\u95a2\u3057\u3066\u306e\u8ad6\u6587\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001
\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u611f\u67d3\u306b\u5bfe\u3059\u308b\u88dc\u4e2d\u76ca\u6c17\u6e6f\u306e\u52b9\u679c\u306b\u3064\u3044\u3066
\u66f8\u304b\u308c\u305f\u8ad6\u6587\u304c\u3042\u3063\u305f\u306e\u3067\u8aad\u3093\u3067\u307f\u307e\u3057\u305f\u3002

\u4ee5\u524d\u304b\u3089\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u4e88\u9632\u306b
\u88dc\u4e2d\u76ca\u6c17\u6e6f\u304c\u6709\u52b9\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002
\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c
\u305d\u306e\u307e\u307eSARS-Cov-2\u306b\u3082\u3042\u3066\u306f\u307e\u308b\u306e\u304b\u3069\u3046\u304b\u306f
\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u53c2\u8003\u306b\u306a\u308b\u3068\u601d\u3044\u307e\u3059\u3002

\u201dEffect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the survival of mice infected with influenza virus\u201d
\uff08\u65e5\u672c\u306e\u6f22\u65b9\u85ac\u3067\u3042\u308b\u88dc\u4e2d\u76ca\u6c17\u6e6f\uff08TJ-41\uff09\u304c\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u30de\u30a6\u30b9\u306e\u751f\u5b58\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff09
Antiviral Research\uff1aVolume 44, Issue 2, December 1999, Pages 103-111<\/a>
\uff08abstract\uff08\u8981\u65e8\uff09\u306e\u307f\u3067\u3001\u672c\u6587\u95b2\u89a7\u306f\u6709\u6599\u3067\u3059\uff09
\u30c4\u30e0\u30e9\u3055\u3093\u306e\u7814\u7a76\u6240\u304b\u30891999\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u8ad6\u6587\u3067\u3059\u3002

\u30de\u30a6\u30b9\u306b7\u65e5\u524d\u304b\u3089\u88dc\u4e2d\u76ca\u6c17\u6e6f\u3092\u6295\u4e0e\u3057\u3066\u304a\u304d\u3001
\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u3092\u611f\u67d3\u3055\u305b\u305f\u7fa4\uff08\u4e88\u9632\uff0f\u6cbb\u7642\u7fa4\uff09\u3068\u3001
\u30a6\u30a4\u30eb\u30b9\u3092\u611f\u67d3\u3055\u305b\u3066\u304b\u3089\u88dc\u4e2d\u76ca\u6c17\u6e6f\u3092\u6295\u4e0e\u3057\u305f\u7fa4\uff08\u6cbb\u7642\u7fa4\uff09\u3001
\u84b8\u7559\u6c34\u3092\u6295\u4e0e\u3057\u305f\u7fa4\uff08\u5bfe\u7167\u7fa4\uff09\u3067\u52b9\u679c\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002
\u88dc\u4e2d\u76ca\u6c17\u6e6f\u306f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c4\u65e5\u76ee\u307e\u3067\u6295\u4e0e\u3057\u3066\u3044\u308b\u69d8\u3067\u3059\u3002

\u6295\u4e0e\u5f8c21\u65e5\u9593\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u5e73\u5747\u751f\u5b58\u65e5\u6570\u306f\u3001
\u4e88\u9632\uff0f\u6cbb\u7642\u7fa4\u306716.8\u00b11.8\u65e5\u3001
\u6cbb\u7642\u7fa4\u304c12.6\u00b12.0\u65e5\u3001
\u5bfe\u7167\u7fa4\u304c10.5\u00b11.8\u65e5\u3067\u3001
\u3044\u305a\u308c\u3082\u5bfe\u7167\u7fa4\u3088\u308a\u751f\u5b58\u65e5\u6570\u306f\u5ef6\u9577\u3057\u307e\u3057\u305f\u304c\u3001
\u6cbb\u7642\u306e\u307f\u306e\u6295\u4e0e\u3088\u308a\u3001
\u4e88\u9632\u7684\u306b\u6295\u4e0e\u3055\u308c\u3066\u3044\u305f\u65b9\u304c\u52b9\u679c\u7684\u3068\u3044\u3046\u7d50\u679c\u3067\u3057\u305f\u3002

\u6b21\u306b\u4e88\u9632\uff0f\u6cbb\u7642\u7fa4\u306b\u304a\u3044\u3066\u3001
\u6295\u4e0e\u91cf\u3092\u4f53\u91cd\u3042\u305f\u308a1\u65e5\u300110mg\uff0c100mg\uff0c1000mg\u3068
\u5909\u3048\u306621\u65e5\u76ee\u306e\u751f\u5b58\u7387\u306b\u5dee\u304c\u51fa\u308b\u304b\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002

21\u65e5\u76ee\u306e\u751f\u5b58\u7387\u306f\u3001 \u84b8\u7559\u6c34\u306e\u5834\u5408\u304c40\uff05\u306b\u5bfe\u3057\u3066\u3001
10mg\uff0fkg\u306780\uff05\u3001100mg\uff0fkg\u306780\uff05\u30011000mg\uff0fkg\u306784\uff05
\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u307b\u3068\u3093\u3069\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3002
\uff08\u3053\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3059\u308b\u3068\u3001\u88dc\u4e2d\u76ca\u6c17\u6e6f\u3092\u611f\u67d3\u4e88\u9632\u3067\u7528\u3044\u308b\u5834\u5408\u3001
\u3000\u305d\u308c\u307b\u3069\u91cf\u306f\u591a\u304f\u306a\u304f\u3066\u3082\u3088\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\uff09

\u6b21\u306b\u3001\u3053\u306e\u6642\u306e\u30de\u30a6\u30b9\u306e\u80ba\u80de\u306e\u4e2d\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u5f37\u3055\u3092
2\uff0c4\uff0c7\u65e5\u5f8c\u306b\u3064\u3044\u3066\u305d\u308c\u305e\u308c\u5bfe\u7167\u7fa4\u3068\u3067\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002

\u80ba\u80de\u306e\u4e2d\u306e\u30a6\u30a4\u30eb\u30b9\u306f\u30014\u65e5\u76ee\u306b\u306f\u6709\u610f\u5dee\u3092\u3082\u3063\u3066
\u88dc\u4e2d\u76ca\u6c17\u6e6f\u3092\u6295\u4e0e\u3055\u308c\u305f\u30de\u30a6\u30b9\u306e\u65b9\u304c\u529b\u304c\u5f31\u3063\u3066\u3044\u307e\u3057\u305f\u3002
7\u65e5\u76ee\u306f\u5bfe\u7167\u7fa4\u3068\u306e\u9593\u306e\u5dee\u306f\u7e2e\u307f\u3001\u6709\u610f\u5dee\u304c\u306a\u304f\u306a\u308a\u3057\u307e\u305f\u304c\u3001
\u305d\u308c\u3067\u3082\u5bfe\u7167\u7fa4\u3088\u308a\u30a6\u30a4\u30eb\u30b9\u304c\u6e1b\u5f31\u3057\u3066\u3044\u308b\u50be\u5411\u306f\u307f\u3089\u308c\u307e\u3059\u3002
\uff08\u3053\u308c\u306f\u88dc\u4e2d\u76ca\u6c17\u6e6f\u30924\u65e5\u76ee\u307e\u3067\u3057\u304b\u6295\u4e0e\u3057\u306a\u304b\u3063\u305f
\u3000\u304b\u3089\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002\uff09

\u6b21\u306b\u3001\u3069\u306e\u69d8\u306b\u3057\u3066\u88dc\u4e2d\u76ca\u6c17\u6e6f\u304c
\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u611f\u67d3\u3092\u8efd\u6e1b\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u691c\u8a0e\u304c\u306a\u3055\u308c\u3066\u307e\u3059\u3002

\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u524d\u3068\u611f\u67d3\u5f8c\uff1a2\u30014\u30017\u65e5\u76ee\u306b
\u80ba\u80de\u6d17\u6d44\u6db2\u306e\u4e2d\u306eIL-1\u03b1\u3001IL-6\u3001GM-CSF\u3001TNF-\u03b1\u3001INF-\u03b3\u3001
\u3068\u3044\u3063\u305f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6e2c\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002

\u7d50\u679c\u306f\u3001TNF-\u03b1\u304a\u3088\u3073IFN-\u03b3\u3092\u9664\u3044\u3066\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30ec\u30d9\u30eb\u304c
4\u65e5\u76ee\u306b\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002

\u6b21\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08INF\uff09\u306e\u8a98\u5c0e\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u3042\u308a\u307e\u3057\u305f\u3002
\u84b8\u7559\u6c34\u6295\u4e0e\u7fa4\u3067\u306f\u3001INF\u306f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5f8c2\u65e5\u305f\u3063\u3066\u3082\u5897\u52a0\u305b\u305a\u3001
4\u65e5\u76ee\u306b\u306a\u3063\u3066\u6025\u306b\u5897\u3048\u3066\u3044\u307e\u3059\u3002
\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u88dc\u4e2d\u76ca\u6c17\u6e6f\u6295\u4e0e\u7fa4\u3067\u306f\u3001
2\u65e5\u5f8c\u304b\u3089\u3059\u3067\u306b\u6709\u610f\u306bINF\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002
4\u65e5\u5f8c\u306b\u306f\u5897\u52a0\u306f\u898b\u3089\u308c\u308b\u3082\u306e\u306e\u3001
\u3080\u3057\u308d\u84b8\u7559\u6c34\u6295\u4e0e\u7fa4\u3068\u6bd4\u3079\u3066\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3059\u3002

\u3053\u306e\u5897\u52a0\u3057\u3066\u3044\u308bINF\u306f\u3001
\u6297\u30de\u30a6\u30b9INF-\u03b1\/\u03b2\u6297\u4f53\u306a\u3069\u3092\u7528\u3044\u3066\u4e2d\u548c\u3057\u3066\u307f\u305f\u3068\u3053\u308d\u3001
INF-\u03b1\u306e\u5897\u52a0\u3060\u3068\u308f\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002

\u3053\u308c\u306f\u3069\u3046\u3044\u3046\u3053\u3068\u3067\u3057\u3087\u3046\u304b\uff1f
\u3053\u3053\u3067\u3001\u4ee5\u524d\u7d39\u4ecb\u3057\u305f\u8ad6\u6587\u3092\u601d\u3044\u51fa\u3057\u3066\u304f\u3060\u3055\u3044\u3002
\uff1eCOVID-19\u306b\u95a2\u9023\u3059\u308b\u8ad6\u65873<\/a>
\u201dType I and Type III Interferons ? Induction, Signaling, Evasion, and Application to Combat COVID-19\u201d
\"\"

\u30a6\u30a4\u30eb\u30b9\u306b\u521d\u611f\u67d3\u3057\u305f\u5834\u5408\u3001\u3059\u3050\u306b\u306fT\u7d30\u80de\u3084B\u7d30\u80de\u306f\u50cd\u304d\u307e\u305b\u3093\u3002
\u6700\u521d\u306b\u7e70\u308a\u51fa\u3055\u308c\u308b\u306e\u306f
\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u81ea\u7136\u514d\u75ab\u3067\u3059\u3002
\u3053\u308c\u304c\u3059\u3050\u306b\u52d5\u54e1\u3055\u308c\u305f\u3089\u3001\u30a6\u30a4\u30eb\u30b9\u306f\u65e9\u671f\u306b\u6392\u9664\u3055\u308c\u3001
\u5897\u6b96\u305b\u305a\u306b\u611f\u67d3\u306f\u7d42\u4e86\u3057\u307e\u3059\u3002
\u6700\u521d\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306e\u5206\u6ccc\u304c\u901f\u3084\u304b\u306b\u884c\u308f\u308c\u306a\u3044\u3068\u3001
\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u3082\u3059\u3059\u307f\u3001
\u5468\u56f2\u304b\u3089\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u904e\u5270\u306b\u5206\u6ccc\u3055\u308c\u3066
\u708e\u75c7\u7d30\u80de\u304c\u6575\u5473\u65b9\u95a2\u4fc2\u306a\u304f\u7834\u58ca\u3057\u3066\u708e\u75c7\u3092\u93ae\u3081\u3088\u3046\u3068\u3059\u308b\u306e\u3067
\u6b63\u5e38\u306e\u7d44\u7e54\u307e\u3067\u3084\u3089\u308c\u3066\u3057\u307e\u3044\u8eab\u4f53\u306b\u5927\u304d\u306a\u30c0\u30e1\u30fc\u30b8\u304c\u52a0\u308f\u308a\u307e\u3059\u3002

\u3067\u3059\u306e\u3067\u3001
\u88dc\u4e2d\u76ca\u6c17\u6e6f\u6295\u4e0e\u30de\u30a6\u30b9\u30672\u65e5\u76ee\u306bINF\u304c\u901f\u3084\u304b\u306b\u5897\u52a0\u3059\u308b
\u2191\u3053\u3053\u304c\u30dd\u30a4\u30f3\u30c8\u306a\u3093\u3060\u3068\u601d\u3044\u307e\u3059\u3002
\u305d\u306e\u7d50\u679c\u3001\u708e\u75c7\u306f\u8efd\u304f\u3066\u6e08\u3080\u306e\u3067\u3001
4\u65e5\u5f8c\u306eINF\u306e\u5206\u6ccc\u306f\u6291\u5236\u3055\u308c\u308b\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002

\u305d\u308c\u306b\u5bfe\u3057\u3066\u3001\u84b8\u7559\u6c34\u304c\u6295\u4e0e\u3055\u308c\u305f\u5bfe\u7167\u7fa4\u3067\u306f\u3001
INF\u306e\u8a98\u5c0e\u304c\u9045\u308c\u3066\u8d77\u3053\u308a\u3001
\u7d50\u679c\u7684\u306b\u5927\u91cf\u5206\u6ccc\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002
\u3053\u308c\u306f\u3001\u5bfe\u5fdc\u306e\u9045\u308c\u3092\u53d6\u308a\u623b\u3059\u305f\u3081\u3001
\u306a\u3093\u3068\u304b\u5fdc\u63f4\u3092\u547c\u307c\u3046\u3068\u3059\u308b\u3057\u304f\u307f\u306a\u3093\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001
\u7d50\u679c\u7684\u306b\u3053\u308c\u304c\u75be\u60a3\u306e\u91cd\u75c7\u5316\u306b\u3064\u306a\u304c\u308b\u69d8\u3067\u3059\u3002

\u5b9f\u969b\u306b\u201dType I and Type III\u30fb\u30fb\u30fb\u201d\u306e\u8ad6\u6587\u306b\u306f\u3001
\u300cINF\u306e\u4e0a\u6607\u306f\u75be\u60a3\u306e\u60aa\u5316\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u300d
\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002
\u81ea\u7136\u514d\u75ab\u306eINF\u306f\u521d\u671f\u306b\u3055\u3063\u3068\u50cd\u3044\u3066\u3001
\u3055\u3063\u3068\u6d88\u3048\u3066\u3044\u304f\u306e\u304c\u7406\u60f3\u306e\u5f62\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002
<\/p>\n\n\n\n

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