{"id":7398,"date":"2021-01-07T08:28:00","date_gmt":"2021-01-06T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=7398"},"modified":"2022-04-21T22:48:14","modified_gmt":"2022-04-21T13:48:14","slug":"covid-19%e9%87%8d%e7%97%87%e5%8c%96%e3%81%ae%e3%82%ab%e3%82%ae","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=7398","title":{"rendered":"COVID-19\u91cd\u75c7\u5316\u306e\u30ab\u30ae"},"content":{"rendered":"\n

\u4eca\u56de\u306e\u8ad6\u6587\u306f\u3053\u308c\uff1a
\u201dSynergism of TNF-\u03b1 and IFN-\u03b3 Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes\u201d
\uff08Google\u7ffb\u8a33\uff1aTNF-\u03b1\u3068IFN-\u03b3\u306e\u76f8\u4e57\u4f5c\u7528\u306f\u3001SARS-CoV-2\u611f\u67d3\u304a\u3088\u3073\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b7\u30e7\u30c3\u30af\u75c7\u5019\u7fa4\u306b\u304a\u3044\u3066\u708e\u75c7\u6027\u7d30\u80de\u6b7b\u3001\u7d44\u7e54\u640d\u50b7\u3001\u304a\u3088\u3073\u6b7b\u4ea1\u7387\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\uff09

\u51fa\u5178\u306fCell\u306711\u6708\u306b\u30cd\u30c3\u30c8\u3067\u516c\u958b<\/a>\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001
\u96d1\u8a8c\u3068\u3057\u3066\u306f2021\u5e741\u67087\u65e5\u7248\u306e\u69d8\u3067\u3059\u3002
doi.org\/10.1016\/j.cell.2020.11.025<\/a>\uff08\u4e0a\u306e\u30ea\u30f3\u30af\u3068\u540c\u3058\uff09

\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\uff08COVID-19\uff09\u306f\u3001
\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u3066\u3082\u7121\u75c7\u72b6\u306e\u4eba\u304b\u3089\u6b7b\u306b\u81f3\u308b\u4eba\u307e\u3067
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\u5bfe\u51e6\u6cd5\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3059\u3002
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\u3082\u3046\u4e00\u3064\u306f\u80ba\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u5168\u8eab\u7684\u306a\u7d44\u7e54\u306e\u708e\u75c7\u3068\u640d\u50b7\u3002

\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u304c
\u95a2\u9023\u3059\u308b\u3053\u3068\u306f\u65e9\u304f\u304b\u3089\u308f\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001
\u305d\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u304a\u3053\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f
\u307e\u3060\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002
\u4eca\u56de\u3001\u305d\u308c\u3092\u8abf\u3079\u305f\u306e\u304c\u3053\u306e\u8ad6\u6587\u3002

\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u304c\u81d3\u5668\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001
\u7d30\u80de\u6b7b\u304c\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002
\u3053\u306e\u7d30\u80de\u6b7b\u306b\u306f3\u7a2e\u985e\u3042\u3063\u3066\u3001
\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\uff08Pyroptosis\uff09
\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08Apoptosis\uff09
\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\uff08Necroptosis\uff09
\u3068\u3044\u3046\u306e\u304c\u3042\u3063\u3066\u3001\u5408\u308f\u305b\u3066 PANoptosis\u3068\u547c\u3076\u305d\u3046\u3067\u3059\u3002

\u3053\u308c\u307e\u3067\u306eCOVID-19\u306e\u7814\u7a76\u304b\u3089\u3001
\u4e2d\u7b49\u5ea6\u307e\u305f\u306f\u91cd\u5ea6\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u3001
\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL\uff09-6\u3001IL-18\u3001IFN-\u03b3\u3001IL-15\u3001TNF\u3001IL-1\u03b1\u3001
IL-1\u03b2\u3001\u304a\u3088\u3073IL-2\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002

\u3053\u306e\u4e2d\u306e\u3069\u308c\u304c\u3001\u7279\u306b\u91cd\u75c7\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u306e\u304b\u3092\u3001
\u9aa8\u9ac4\u7531\u6765\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3053\u308c\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6295\u4e0e\u3057\u3066\u3001
\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002

\u305d\u306e\u7d50\u679c\u3001\u4e00\u3064\u4e00\u3064\u3092\u500b\u5225\u306b\u6295\u4e0e\u3057\u305f\u5834\u5408\u306f\u3001
\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3057\u306a\u304b\u3063\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001
\u3059\u3079\u3066\u3092\u30ab\u30af\u30c6\u30eb\u3057\u305f\u3082\u306e\u3092\u6295\u4e0e\u3057\u305f\u6642\u306b\u306f\u3001
\u5f37\u3044\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002
\"\"

\u3068\u306a\u308b\u3068\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u3067
\u7d30\u80de\u6b7b\u304c\u8a98\u5c0e\u8a98\u5c0e\u3055\u308c\u308b\u306e\u3060\u308d\u3046\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002
\u305d\u3053\u3067\u3001\u305d\u308c\u305e\u308c2\u7a2e\u985e\u3092\u5408\u308f\u305b\u3066\u6295\u4e0e\u3057\u305f\u306e\u304c\u3053\u306e\u56f3\u3002
\"\"

IFN-\u03b3\u3068TNF-\u03b1\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u6295\u4e0e\u3057\u305f\u6642\u306e\u307f\u3001
\u3059\u3079\u3066\u3092\u4e00\u7dd2\u306b\u6295\u4e0e\u3057\u305f\u6642\u3068\u307b\u307c\u540c\u3058\u304f\u3089\u3044\u306e
\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001
\u4ed6\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002

INF-\u03b3\u3001TNF-\u03b1\u3068\u3001\u305d\u308c\u3089\u3092\u5408\u308f\u305b\u3066\u6295\u4e0e\u3057\u305f\u5834\u5408\u306e
\u7d30\u80de\u6b7b\u306e\u5272\u5408\u3092\u6642\u9593\u7d4c\u904e\u3067\u307f\u305f\u3082\u306e\u3067\u3082\u3001
\u7642\u6cd5\u5408\u308f\u305b\u3066\u6295\u4e0e\u3057\u305f\u5834\u5408\u306b24\u6642\u9593\u7d4c\u904e\u3057\u305f\u9803\u304b\u3089\u3001
\u6025\u306b\u5897\u52a0\u3057\u3066\u304f\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002
\"\"

\u3064\u307e\u308aINF-\u03b3\u3068TNF-\u03b1\u306e\u76f8\u4e57\u4f5c\u7528\u304c\u7d30\u80de\u6b7b\u306e\u8a98\u5c0e\u306b
\u91cd\u8981\u3067\u3042\u308b\u3068\u308f\u304b\u3063\u305f\u3068\u306e\u3067\u3059\u3002

\u305d\u3053\u3067\u3001INF-\u03b3\u3068TNF-\u03b1\u3092\u30de\u30a6\u30b9\u306b\u5927\u91cf\u6295\u4e0e\u3057\u3066\u307f\u305f\u3068\u3053\u308d\u3001
INF-\u03b3\u3060\u3051\u3001TNF-\u03b1\u3060\u3051\u3092\u6295\u4e0e\u3067\u306f
\u6709\u610f\u306a\u6b7b\u4ea1\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001
INF-\u03b3\u3068TNF-\u03b1\u306e\u4e21\u65b9\u3092\u6295\u4e0e\u3057\u305f\u5834\u5408\u306b\u306f
\u76f8\u4e57\u7684\u306b\u6b7b\u4ea1\u7387\u304c\u4e0a\u304c\u3063\u305f\u306e\u3060\u305d\u3046\u3067\u3059\u3002

\u305d\u3057\u3066\u3055\u3089\u306b\u3001\u540c\u6642\u6295\u4e0e\u3057\u305f\u5834\u5408\u3001COVID-19\u3067\u89b3\u5bdf\u3055\u308c\u308b
\u4ed6\u306e\u691c\u67fb\u5024\u30fb\u30fb\u30fbSLT\u3001AST\u3001BUN\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u7b49
\u3068\u3044\u3063\u305f\u7570\u5e38\u3082\u540c\u3058\u3088\u3046\u306b\u89b3\u5bdf\u3055\u308c\u305f\u305d\u3046\u3067\u3059\u3002

\u3053\u306e\u8ad6\u6587\u3067\u306f\u3055\u3089\u306b\u3001INF-\u03b3\u3068TNF-\u03b1\u304c\u7d30\u80de\u306b\u50cd\u3044\u3066\u3001
\u3069\u306e\u3088\u3046\u306b\u7d30\u80de\u6b7b\uff08PANoptosis\uff09\u3092\u6765\u3059\u306e\u304b\u3068\u3044\u3046
\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3082\u8003\u5bdf\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002

\u305d\u3057\u3066\u3001\u6700\u7d42\u7684\u306b\u91cd\u75c7\u5316\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u3001
\u3053\u308c\u3089\u306e\u4e2d\u548c\u6297\u4f53\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001
\u6b7b\u4ea1\u7387\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u30de\u30a6\u30b9\u306e\u5b9f\u9a13\u3067\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002

\u3053\u3046\u3057\u305f\u4e2d\u548c\u6297\u4f53\u306b\u3088\u308a\u6cbb\u7642\u306f\u3001\u4eca\u5f8c\u3001
COVID-19\u306e\u91cd\u75c7\u5316\u306e\u4e88\u9632\u3060\u3051\u3067\u306a\u304f\u3001
\u4ed6\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u4ecb\u3057\u305f\u708e\u75c7\u6027\u75be\u60a3\u306e\u6cbb\u7642\u3001
\u4f8b\u3048\u3070\u6557\u8840\u75c7\u3084\u8840\u7403\u8caa\u98df\u6027\u30ea\u30f3\u30d1\u7d44\u7e54\u7403\u75c7\u306a\u3069\u306e
\u708e\u75c7\u6027\u75be\u60a3\u306b\u3082\u6709\u7528\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u5bdf\u3057\u3066\u3044\u307e\u3059\u3002

<\/p>\n","protected":false},"excerpt":{"rendered":"

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