{"id":7348,"date":"2020-12-27T08:28:00","date_gmt":"2020-12-26T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=7348"},"modified":"2022-04-21T22:48:50","modified_gmt":"2022-04-21T13:48:50","slug":"covid-19%e3%81%ab%e9%96%a2%e9%80%a3%e3%81%99%e3%82%8b%e8%ab%96%e6%96%871","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=7348","title":{"rendered":"COVID-19\u306b\u95a2\u9023\u3059\u308b\u8ad6\u65871"},"content":{"rendered":"\n

\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\uff08COVID-19\uff09\u306b\u5bfe\u3057\u3066
\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u304c
\u6025\u30d4\u30c3\u30c1\u3067\u3059\u3059\u307f\u3001
\u305d\u308d\u305d\u308d\u65e5\u672c\u3067\u3082\u63a5\u7a2e\u53ef\u80fd\u306b\u306a\u308d\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\u559c\u3070\u3057\u3044\u3053\u3068\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001
\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u3057\u3063\u304b\u308a\u3068\u541f\u5473\u3057\u3066\u307b\u3057\u3044\u3068\u601d\u3044\u307e\u3059\u3002

\u305f\u3060\u3001\u30ef\u30af\u30c1\u30f3\u3067\u5168\u3066\u304c\u89e3\u6c7a\u3059\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u3082\u306a\u304f\u3001
\u7f79\u3063\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306b\u3082\u901f\u3084\u304b\u6cbb\u308b\u3088\u3046\u306a\u3001
\u305d\u3093\u306a\u6cbb\u7642\u85ac\u3082\u51fa\u3066\u304d\u3066\u6b32\u3057\u3044\u3082\u306e\u3067\u3059\u3002

\u4e16\u754c\u4e2d\u3067\u3044\u308d\u3044\u308d\u306a\u85ac\u5264\u306e\u958b\u767a\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3057\u3001
\u65e2\u5b58\u306e\u85ac\u5264\u306e\u4e2d\u3067\u52b9\u679c\u306e\u3042\u308b\u85ac\u5264\u306e\u6a21\u7d22\u3082\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002

\u3067\u3001\u4eca\u56de\u306f\u65e2\u5b58\u306e\u85ac\u5264\u3092\u7528\u3044\u305f\u7d50\u679c\u306e\u8ad6\u6587\u3092\u4e00\u3064\u3002
\u201dRepurposed Antiviral Drugs for Covid-19 ? Interim WHO Solidarity Trial Results<\/a>\u201d
\uff08Covid-19\u306e\u305f\u3081\u306e\u518d\u5229\u7528\u3055\u308c\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac?\u66ab\u5b9a\u7684\u306aWHO\u9023\u5e2f\u8a66\u9a13\u306e\u7d50\u679c\uff09\u30fb\u30fb\u30fb\u8a33\u306fGoogle\u4efb\u305b(^_^;)
\u51fa\u5178\u306fNEJM\u30002020\/12\/2

\u3053\u306e\u8ad6\u6587\u3067\u306f\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u3001\u30d2\u30c9\u30ed\u30ad\u30b7\u30af\u30ed\u30ed\u30ad\u30f3\u3001\u30ed\u30d4\u30ca\u30d3\u30eb\u3001
\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b21a\u306e4\u5264\u306b\u3064\u3044\u3066\u306e\u5831\u544a\u3002

30\u304b\u56fd\u306e405\u306e\u75c5\u9662\u3067\u3001
\u30ec\u30e0\u30c7\u30b7\u30d9\u30eb\u3000\u30002750\u540d
\u30d2\u30c9\u30ed\u30ad\u30b7\u30af\u30ed\u30ed\u30ad\u30f3\u3000954\u540d
\u30ed\u30d4\u30ca\u30d3\u30eb\u30001411\u540d
\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u30002063\u540d\uff08\u3046\u3061651\u540d\u306f\u30ed\u30d4\u30ca\u30d3\u30eb\u4f75\u7528\uff09
\u3068\u3001\u3053\u308c\u3089\u306e\u6cbb\u9a13\u85ac\u306a\u3057\u30004088\u540d\u3092\u6bd4\u8f03\u3002

\u7d50\u679c\u3068\u3057\u3066\u306f\u3001
\u5168\u4f53\u7684\u306a\u6b7b\u4ea1\u7387\u3001\u4eba\u5de5\u547c\u5438\u5668\u306e\u5c0e\u5165\u7387\u3001\u304a\u3088\u3073\u5165\u9662\u671f\u9593\u306b\u3064\u3044\u3066\u3001
\u307b\u3068\u3093\u3069\u307e\u305f\u306f\u307e\u3063\u305f\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002
\u3046\u30fc\u3093\u3001\u6b8b\u5ff5\uff01\u3002

********<\/p>\n\n\n\n

\u6b21\u306e\u8ad6\u6587\u306b\u79fb\u308a\u307e\u3057\u3087\u3046\u3002

\u201dCombining Antivirals and Immunomodulators to Fight COVID-19<\/a>\u201d
\uff08COVID-19\u3068\u6226\u3046\u305f\u3081\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u5264\u3068\u514d\u75ab\u8abf\u7bc0\u5264\u306e\u7d44\u307f\u5408\u308f\u305b\uff09
\u51fa\u5178\u306fTrends in Immunology 2020\/11\/13

\u3053\u306e\u8ad6\u6587\u306f\u3001\u7814\u7a76\u7d50\u679c\u306e\u5831\u544a\u3068\u3044\u3046\u3088\u308a\u3001
COVID-19\u306e\u751f\u3058\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u8aac\u3068\u3001
\u305d\u3053\u304b\u3089\u8003\u3048\u3089\u308c\u308b\u6226\u7565\u306e\u63d0\u6848\u3067\u3059\u3002

\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u3068\u3057\u3066\u73fe\u5728\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001
C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HCV\uff09\u3068\u5f8c\u5929\u6027\u514d\u75ab\u4e0d\u5168\u75c7\u5019\u7fa4\u306eHIV\u3001
\u304a\u3088\u3073\u5358\u7d14\u30d8\u30eb\u30da\u30b9\uff08HSV\uff09\u30fb\u5e2f\u72b6\u75b1\u75b9\u30d8\u30eb\u30da\u30b9\uff08VZV\uff09\u3067\u3059\u3002

\u3053\u3046\u3057\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u5264\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u30e9\u30a4\u30d5\u30b5\u30a4\u30af\u30eb\u306e
\u5c11\u306a\u304f\u3068\u3082\u4e00\u90e8\u3092\u6a19\u7684\u3068\u3057\u3066\u3001
\u521d\u671f\uff08\u4fb5\u5165\uff09\u307e\u305f\u306f\u5f8c\u671f\uff08\u8907\u88fd\uff09\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002
\"\"
\u3053\u306e\u56f3\u306e\u5de6\u4e0a\u304c\u30a6\u30a4\u30eb\u30b9\u306b\u66b4\u9732\u21d2\u4fb5\u5165\u21d2\u8907\u88fd\u3092\u793a\u3057\u307e\u3059\u3002
\u514d\u75ab\u53cd\u5fdc\u3068\u3057\u3066\u3046\u307e\u304fINF\u03b1\/\u03b2\u304c\u50cd\u304f\u3068\u3001
\u611f\u67d3\u3057\u305f\u7d30\u80de\u304c\u6b7b\u3093\u3067\u62e1\u5927\u518d\u751f\u7523\u304c\u884c\u308f\u308c\u305a\u53ce\u675f\u3057\u307e\u3059\u3002

\u3057\u304b\u3057\u3001\u514d\u75ab\u53cd\u5fdc\u304c\u9577\u304f\u7d9a\u304f\u3068\u3001
\u514d\u75ab\u7d30\u80de\u304b\u3089\u69d8\u3005\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u653e\u51fa\u3055\u308c
\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001
\u5468\u56f2\u306e\u7d44\u7e54\uff08\u80ba\u306a\u3069\uff09\u306e\u708e\u75c7\u304c\u751f\u3058\u3066\u91cd\u75c7\u5316\u3057\u307e\u3059\uff08\u53f3\u4e0a\uff09\u3002

\u3053\u306e\u56f3\u306e\u7d3a\u8272\u306e\u90e8\u5206\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u5264\u3067\u3059\u3002
\u5de6\u4e0a\u306b\u30ec\u30e0\u30c7\u30b7\u30d9\u30eb\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002

\u3053\u3061\u3089\u306e\u56f3\u306f\u3001\u5148\u306e\u56f3\u306e\u5de6\u4e0a\u3060\u3051\u3092\u53d6\u308a\u51fa\u3057\u305f\u3082\u306e\u3067\u3059\u3002
\"\"
SARS-CoV-2\u304c\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d202\uff08ACE2)\u3084
\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u9175\u7d20\uff08TMPRESS2\uff09\u3092\u5229\u7528\u3057\u3066\u3001
\u7d30\u80de\u5185\u306b\u5438\u3044\u8fbc\u307e\u308c\u3066\u3044\u304f\u69d8\u5b50\u304b\u6a21\u5f0f\u56f3\u3068\u3057\u3066\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002

\u305d\u3057\u3066\u5438\u3044\u8fbc\u307e\u308c\u305f\u30a6\u30a4\u30eb\u30b9\u304b\u3089RNA\u304c\u51fa\u3066\u304d\u3066\u3001
\u305d\u306e\u8a2d\u8a08\u56f3\u3092\u3082\u3068\u306b\u65b0\u3057\u3044\u30a6\u30a4\u30eb\u30b9\u304c\u7523\u751f\u3055\u308c\u3001
\u6700\u7d42\u7684\u306b\u7d30\u80de\u306e\u5916\u306b\u51fa\u3066\u884c\u304d\u307e\u3059\u3002

\u3053\u306e\u56f3\u306e\u8d64\u3044\u90e8\u5206\u304c\u8ad6\u7406\u7684\u306b\u8003\u3048\u3066\u52b9\u679c\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u308b
\u85ac\u5264\u306e\u50cd\u304f\u5834\u6240\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002
\u5de6\u4e0a\u306eCamostat\u306f\u6162\u6027\u81b5\u708e\u306e\u85ac\u3067\u3059\u304c\u3001
TMPRESS2\u306e\u50cd\u304d\u3092\u6291\u3048\u308b\u4f5c\u7528\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3067\u3001
\u30cd\u30c3\u30c8\u3067\u8abf\u3079\u3066\u307f\u307e\u3059\u30682020\/11\/10\u306e\u6bb5\u968e\u3067
\u81e8\u5e8a\u8a66\u9a13\u306e\u7b2c3\u76f8\u304c\u59cb\u307e\u3063\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002
https:\/\/www.mixonline.jp\/tabid55.html?artid=70141<\/a>

\u53f3\u4e0a\u306b\u306fOseltamivir\u3068\u66f8\u3044\u3066\u3042\u3063\u3066\u300c\uff1f\u300d\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002
\u3053\u308c\u306f\u5148\u767a\u54c1\u3067\u8a00\u3048\u3070\u6297\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u85ac\u30bf\u30df\u30d5\u30eb\u306e\u3053\u3068\u3067\u3059\u306d\u3002
\u3082\u3057\u3053\u308c\u304c\u52b9\u3044\u3066\u3044\u305f\u3089\u3001
\u4eca\u3054\u308d\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306b\u306f\u306a\u3063\u3066\u3044\u306a\u3044\u3067\u3057\u3087\u3046\u306d\u3002

\u3053\u308c\u306f\u3001Oseltamivir\u304c\u30ce\u30a4\u30e9\u30df\u30cb\u30c0\u30fc\u30bc\u3068\u3044\u3046\u3001
\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u5185\u3067\u5897\u3048\u305f\u3042\u3068\u3001
\u5916\u306b\u51fa\u3088\u3046\u3068\u3059\u308b\u969b\u306b\u5fc5\u8981\u306a\u9175\u7d20\u3092
\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u305d\u3046\u306a\u3093\u3067\u3059\u304c\u3001
SARS-CoV-2\u306b\u306f\u3053\u306e\u30ce\u30a4\u30e9\u30df\u30cb\u30c0\u30fc\u30bc\u304c\u306a\u3044\u3089\u3057\u304f\u3001
\u52b9\u304b\u306a\u3044\u3060\u308d\u3046\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002

\u540c\u69d8\u306b\u3001\u56f3\u306e\u4e2d\u592e\u306b
lopinavir\uff08\u30ed\u30d4\u30ca\u30d3\u30eb\uff09\u3001retonavir\uff08\u30ea\u30c8\u30ca\u30d3\u30eb\uff09\u306a\u3069\u304c\u66f8\u3044\u3066\u3042\u308a\u3001
\u3084\u306f\u308a\u300c\uff1f\u300d\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002
\u3053\u308c\u3089\u306e\u85ac\u5264\u306fHIV\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002
HIV\u306e\u30a6\u30a4\u30eb\u30b9\u304c\u5bbf\u4e3b\u306e\u7d30\u80de\u306b\u4f5c\u3089\u305b\u305f\u5927\u304d\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092
\u5c0f\u3055\u306a\u90e8\u54c1\u306b\u5207\u308a\u5206\u3051\u308b\u9175\u7d20\u306a\u3093\u3060\u305d\u3046\u3067\u3001
\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3060\u304b\u3089\u52b9\u304f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u308f\u308c\u307e\u3057\u305f\u304c\u3001
\u4e0a\u306e\u8ad6\u6587\u306b\u3082\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u52b9\u679c\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002

\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001HIV\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u7cfb\u3067\u3042\u308a\u3001
SARS-CoV-2\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f
Cys\u30fcHis\uff08\u30b7\u30b9\u30c6\u30a4\u30f3\uff0f\u30d2\u30b9\u30c1\u30b8\u30f3\uff09\u7cfb\u3067\u30ad\u30e2\u30c8\u30ea\u30d7\u30b7\u30f3\u69d8\u306e\u3082\u306a\u306e\u3067\u3001
\u69cb\u9020\u4e0a\u5168\u304f\u7570\u306a\u308b\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002
\u3060\u304b\u3089\u52b9\u304b\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3057\u3087\u3046\u3002

\u3082\u3046\u4e00\u3064\u52b9\u679c\u304c\u3084\u3084\u7591\u554f\u8996\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001
\uff08\u3053\u306e\u56f3\u3067\u306f\u300c\uff1f\u300d\u306b\u306f\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u304c\uff09
CQ\uff0fHCQ\uff08\u30af\u30ed\u30ed\u30ad\u30f3\uff0f\u30d2\u30c9\u30ed\u30ad\u30b7\u30af\u30ed\u30ed\u30ad\u30f3\uff09\u3067\u3059\u3002
\u3053\u308c\u306f\u6297\u30de\u30e9\u30ea\u30a2\u85ac\u3067\u3001\u50d5\u3082\u5927\u5b66\u6642\u4ee3\u306b\u5bc4\u751f\u866b\u5b66\u3067\u7fd2\u3044\u307e\u3057\u305f\u3002
\u73fe\u5728\u3067\u306f\u30de\u30e9\u30ea\u30a2\u6cbb\u7642\u3088\u308a\u3082\u3001\u6297\u708e\u75c7\u4f5c\u7528\u304b\u3089
SLE\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002

HIV\u306a\u3069\u4ed6\u306e\u30a6\u30a4\u30eb\u30b9\u75be\u60a3\u306b\u3082\u52b9\u679c\u304c\u3042\u308a\u3001
\u671f\u5f85\u3055\u308c\u307e\u3057\u305f\u304c\u3001Naure\u30002020\/7\/22
\u201dMedical research: Assessing the antiviral activity of chloroquine and hydroxychloroquine\u201d\u3067\u306f\u3001
\u9855\u8457\u306a\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u69d8\u3067\u3059\u3002
\uff1e\u533b\u5b66\u7814\u7a76\uff1a\u30af\u30ed\u30ed\u30ad\u30f3\u3068\u30d2\u30c9\u30ed\u30ad\u30b7\u30af\u30ed\u30ed\u30ad\u30f3\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u306e\u8a55\u4fa1<\/a>

\u6b21\u56de\u306b\u7d9a\u304f <\/p>\n","protected":false},"excerpt":{"rendered":"

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