{"id":6956,"date":"2020-06-16T08:28:00","date_gmt":"2020-06-15T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=6956"},"modified":"2022-04-21T22:52:21","modified_gmt":"2022-04-21T13:52:21","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e6%84%9f%e6%9f%93%e7%97%87%e3%81%a8%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95%e3%82%a7%e3%83%ad%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=6956","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u611f\u67d3\u75c7\u3068\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3"},"content":{"rendered":"\n

\u524d\u56de\u7d39\u4ecb\u3057\u307e\u3057\u305f\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb\u306e\u8a18\u4e8b\u3001
\uff1eBCG\u3068\u65b0\u578b\u30b3\u30ed\u30ca\u3001\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068\u3044\u306a\u3044\u3053\u3068\uff08\u5f8c\u7de8\uff09<\/a>
\uff08\u95b2\u89a7\u306b\u306f\u4f1a\u54e1\u767b\u9332\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff09
\u306e\u4e2d\u306b\u3001\u8208\u5473\u6df1\u3044\u8ad6\u6587\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002

\uff1eType I and Type III Interferons ? Induction, Signaling, Evasion, and Application to Combat COVID-19<\/a>
\uff08I\u578b\u30fbIII\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff1a\u8a98\u5c0e\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u56de\u907f\u3068COVID-19\u306e\u6cbb\u7642\u6226\u7565\uff09

\u524d\u56de\u3001\u75c5\u539f\u4f53\u306b\u5bfe\u3059\u308b\u8eab\u4f53\u306e\u9632\u5fa1\u306b\u3001
\u81ea\u7136\u514d\u75ab\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308b\u3068\u66f8\u304d\u307e\u3057\u305f\u3002
\u305d\u306e\u81ea\u7136\u514d\u75ab\u306e\u4e2d\u5fc3\u7684\u5f79\u5272\u306e\u4e00\u3064\u304c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08INF)\u3067\u3059\u3002

\u8eab\u4f53\u306b\u30a6\u30a4\u30eb\u30b9\u304c\u4fb5\u5165\u3057\u3066\u304d\u305f\u3068\u308f\u304b\u308b\u3068\u3001
\u7d30\u80de\u306f\u300c\u52a9\u3051\u3066\uff01\u300d\u3068\u3044\u3046\u30b7\u30b0\u30ca\u30eb\u3092\u51fa\u3057\u307e\u3059\u3002\u3053\u308c\u304cINF\u3067\u3059\u3002
\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u3066\u3001\u7d30\u80de\u306f\u81ea\u3089\u306e\u907a\u4f1d\u5b50\u306e\u4e2d\u304b\u3089\u3001
\u3055\u307e\u3056\u307e\u306a\u30a6\u30a4\u30eb\u30b9\u9000\u6cbb\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3082\u3063\u305f\u907a\u4f1d\u5b50
\uff08\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u523a\u6fc0\u907a\u4f1d\u5b50\uff08ISG\uff09\uff09\u3092\u6d3b\u6027\u5316\u3055\u305b\u307e\u3059\u3002

\u30b3\u30ed\u30ca\u7cfb\uff08SARS\u3001MARS\u3001\u305d\u3057\u3066\u4eca\u56de\u306e\u30a6\u30a4\u30eb\u30b9\u3082\u304a\u305d\u3089\u304f\uff09\u306f\u3001
\u7d30\u80de\u306b\u4fb5\u5165\u3057\u3066\u304d\u305f\u969b\u306b\u30a6\u30a4\u30eb\u30b9RNA\u306e\u9854\u3092
\u76ee\u7acb\u305f\u306a\u304f\u3055\u305b\u308b\u3053\u3068\u3067INF\uff08\u7279\u306bI\u578bINF\uff08INF-I\uff09\uff09\u306e\u7523\u751f\u304c
\u9045\u308c\u308b\u50be\u5411\u304c\u3042\u308b\u3089\u3057\u3044\u306e\u3067\u3059\u3002

\u305d\u306e\u6642\u30a6\u30a4\u30eb\u30b9\u306e\u91cf\u304c\u5c11\u306a\u3051\u308c\u3070\u3001
\u305d\u308c\u3067\u3082\u4f55\u3068\u304b\u7d20\u65e9\u304f\u5bfe\u5fdc\u3057\u3001INF-I\u306e\u30b7\u30b0\u30ca\u30eb\u304cISG\u306b\u5c4a\u304d\u3001
\u8af8\u3005\u306e\u30a6\u30a4\u30eb\u30b9\u99c6\u9664\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u50cd\u3044\u3066
\u30a6\u30a4\u30eb\u30b9\u306f\u8907\u88fd\u3055\u308c\u305a\u306b\u708e\u75c7\u304c\u304a\u3055\u307e\u3063\u3066\u3044\u304f\u305d\u3046\u3067\u3059\u3002

\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u6700\u521d\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u66b4\u9732\u91cf\u304c\u591a\u3044\u3068
INF\u30fcI\u306e\u7523\u751f\u304c\u9045\u308c\u3066\u3057\u307e\u3044\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u99c6\u9664\u3067\u304d\u305a\u306b\u3001
INF-I\u3082\u9577\u3044\u9593\u51fa\u7d9a\u3051\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002

\u3053\u306eINF-I\u306f\u708e\u75c7\u3092\u304a\u3053\u3055\u305b\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u305f\u3081\u3001
\u521d\u671f\u306b\u30ef\u30fc\u3063\u3068\u51fa\u3066\u3082\u3059\u3050\u306b\u53ce\u307e\u308c\u3070
\u7d44\u7e54\u306e\u30c0\u30e1\u30fc\u30b8\u306f\u5c11\u306a\u3044\u306e\u3067\u3059\u304c\u3001
\u9577\u3044\u9593\u51fa\u7d9a\u3051\u308b\u3068\u3001\u5468\u56f2\u3078\u306e\u708e\u75c7\u3082\u3072\u3069\u304f\u306a\u308a\u3001
\u7d44\u7e54\u304c\u713c\u3051\u91ce\u539f\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u3001\u5168\u8eab\u7684\u306a\u5f71\u97ff\u3082\u51fa\u73fe\u3057\u3001
\u91cd\u75c7\u5316\u3078\u3068\u9032\u3080\u539f\u56e0\u306b\u306a\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002
\"\"
\u2191\u30a6\u30a4\u30eb\u30b9\u56e0\u5b50\u3068\u5bbf\u4e3b\u56e0\u5b50\u306e\u4e21\u65b9\u304cIFN\u5fdc\u7b54\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u521d\u671f\u30a6\u30a4\u30eb\u30b9\u91cf\u304c\u5c11\u306a\u3044\u5834\u5408\uff08\u5de6\uff09\u3001IFN\u306f\u65e9\u671f\u306b\u8a98\u5c0e\u3055\u308c\u3001\u611f\u67d3\u3092\u52b9\u679c\u7684\u306b\u53d6\u308a\u9664\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u9ad8\u3044\u30a6\u30a4\u30eb\u30b9\u91cf\uff08\u53f3\uff09\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u56de\u907f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308bIFN\u5fdc\u7b54\u3092\u5f37\u304f\u6291\u5236\u3057\u3001\u8a98\u5c0e\u306e\u9045\u5ef6\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u307e\u305f\u306f\u3001\u9ad8\u9f62\u8005\u3067\u306fIFN\u8a98\u5c0e\u304c\u640d\u306a\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 IFN\u5fdc\u7b54\u304c\u521d\u671f\u306e\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u3092\u5236\u5fa1\u3059\u308b\u306e\u306b\u4e0d\u5341\u5206\u3067\u3042\u308b\u5834\u5408\u3001\u9045\u767a\u6027IFN\u306f\u708e\u75c7\u3068\u80ba\u640d\u50b7\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \uff08google\u7ffb\u8a33\uff09

\u3067\u3059\u304b\u3089\u3001\u611f\u67d3\u306e\u65e9\u671f\u306bINF-I\u304c\u8db3\u3089\u306a\u3044\u306e\u306a\u3089\u3001
\u5916\u304b\u3089\u8db3\u3057\u3066\u3084\u308c\u3070\u7d20\u65e9\u304f\u93ae\u706b\u3067\u304d\u308b\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u6d6e\u4e0a\u3057\u3066\u304d\u307e\u3059\u3002
IFN-I\u304cSARS-CoV-2\u306e\u4e88\u9632\u85ac\u307e\u305f\u306f\u65e9\u671f\u6cbb\u7642\u9078\u629e\u80a2\u3068\u3057\u3066
\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u308f\u3051\u3067\u3059\u3002
\u5b9f\u969b\u306b\u3001INF-I\u306e\u4e00\u7a2e\u3001\u7d44\u307f\u63db\u3048INF-\u03b1\u70b9\u9f3b\u85ac\u3092\u7528\u3044\u305f
\u4e88\u9632\u304c\u6cbb\u9a13\u7684\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002

\u305f\u3060\u3057\u3001INF-I\u306f\u9577\u304f\u4f7f\u3046\u3068\u4eca\u5ea6\u306f\u708e\u75c7\u304c\u91cd\u75c7\u5316\u3059\u308b\u5371\u967a\u304c
\u5f90\u3005\u306b\u5897\u3048\u3066\u304f\u308b\u3068\u3044\u3046\u30b8\u30ec\u30f3\u30de\u304c\u51fa\u3066\u304d\u307e\u3059\u3002
\u3053\u3053\u3067\u767b\u5834\u3059\u308b\u306e\u304cIII\u578bINF\uff08INF-III\uff09\u3067\u3059\u3002

INF-III\uff08INF-\u03bb\uff09\u306e\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u306e\u65b9\u6cd5\u306f\u3001
\u5c40\u6240\u7684\u3067\u3001\u9577\u671f\u7684\u3001\u975e\u708e\u75c7\u6027\u3068\u3044\u3046\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u308b\u305d\u3046\u3067\u3001
\u611f\u67d3\u521d\u671f\u306b\u9f3b\u8154\u5185\u6295\u4e0e\u3084\u5438\u5165\u3092\u3059\u308b\u3053\u3068\u3067\u3001
\u4e0a\u6c17\u9053\u3067\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u5236\u9650\u3057\u80ba\u3078\u306e\u4f1d\u642c\u3092
\u9632\u6b62\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001INF-I\u3067\u99c6\u9664\u3057\u640d\u306d\u305f\u5834\u5408\u306b
\u708e\u75c7\u306e\u62e1\u5927\u3084\u5168\u8eab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306a\u304f\u3001
\u9577\u6642\u9593\u306b\u308f\u305f\u308a\u30a6\u30a4\u30eb\u30b9\u304b\u3089\u7c98\u819c\u4e0a\u76ae\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c
\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002

I\u578b\u3068III\u578b\u306e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3092\u3046\u307e\u304f\u4f7f\u3046\u3053\u3068\u3067\u3001
COVID-19\u304c\u3046\u307e\u304f\u93ae\u5727\u3067\u304d\u308b\u3068\u3044\u3044\u3067\u3059\u306d\u3002

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u524d\u56de\u7d39\u4ecb\u3057\u307e\u3057\u305f\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb\u306e\u8a18\u4e8b\u3001\uff1eBCG\u3068\u65b0\u578b\u30b3\u30ed\u30ca\u3001\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068\u3044\u306a\u3044\u3053\u3068\uff08\u5f8c\u7de8\uff09\uff08\u95b2\u89a7\u306b\u306f\u4f1a\u54e1\u767b\u9332\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff09\u306e\u4e2d\u306b\u3001\u8208\u5473\u6df1\u3044\u8ad6\u6587\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002 \uff1eType I and Type III …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89,6],"tags":[67],"class_list":["post-6956","post","type-post","status-publish","format-standard","hentry","category-covid-19","category-blog","tag-covid-19"],"_links":{"self":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6956"}],"version-history":[{"count":3,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6956\/revisions"}],"predecessor-version":[{"id":6980,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6956\/revisions\/6980"}],"wp:attachment":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}