{"id":6927,"date":"2020-06-09T08:28:00","date_gmt":"2020-06-08T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=6927"},"modified":"2022-04-21T22:53:52","modified_gmt":"2022-04-21T13:53:52","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e6%84%9f%e6%9f%93%e7%97%87%e3%83%9e%e3%82%a4%e3%82%af%e3%83%ad%e3%83%90%e3%82%a4%e3%82%aa%e3%83%bc%e3%82%bf2","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=6927","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u611f\u67d3\u75c7\u3068\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30bf2"},"content":{"rendered":"\n

\u6628\u65e5\u304b\u3089\u306e\u7d9a\u304d
\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306a\u306e\u306b\u306a\u305c\u6297\u751f\u7269\u8cea\uff1f
\u305d\u306e\u5143\u30cd\u30bf\u3067\u3059\u3002

Covid-19 : la piste du microbiote, vers un nouveau paradigme ?<\/a>
\uff08Covid-19\uff1a\u5fae\u751f\u7269\u53e2\u30c8\u30e9\u30c3\u30af\u3001\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u306b\u5411\u3051\u3066\uff1f\uff09
Dimitri Jacques redige le 08 avril 2020 a 14h22

\u4eca\u306f\u4fbf\u5229\u3067\u3059\u306d\u3002\u30d5\u30e9\u30f3\u30b9\u8a9e\u306e\u30b5\u30a4\u30c8\u3067\u3059\u304c\u3001
\u6a5f\u68b0\u7ffb\u8a33\u3067\u5927\u96d1\u628a\u306b\u306f\u8a18\u4e8b\u3092\u8aad\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002

\u3053\u306e\u8a18\u4e8b\u306f\u3001SantePort Royal\u793e\u3068\u3044\u3046\u305f\u3076\u3093\u5065\u5eb7\u98df\u54c1\u3068\u304b
\u6c11\u9593\u85ac\u3092\u4f5c\u3063\u3066\u3044\u308b\u4f1a\u793e\u306eWeb\u306a\u306e\u3067\u3001
\u6700\u7d42\u7684\u306b\u306f\u8178\u5185\u7d30\u83cc\u3092\u3088\u304f\u3057\u307e\u3057\u3087\u3046\u3068\u3044\u3046\u8a71\u304b\u306a\u3001
\u3068\u601d\u3044\u306a\u304c\u3089\u8aad\u3093\u3067\u307f\u307e\u3057\u305f\u3002

\u201dDes chercheurs chinois se sont penches sur les modifications du microbiote chez les patients les plus atteints (ceux qui sont decedes). Le sequencage du microbiote a revele une diminution significative des bifidobacteries et des lactobacilles , principales familles de bacteries symbiotiques, ainsi qu\u2019une augmentation de bacteries opportunistes telles Corynebacterium ou Ruthenibacterium.
\uff08\u4e2d\u56fd\u306e\u7814\u7a76\u8005\u306f\u3001\u6700\u3082\u82e6\u3057\u3093\u3067\u3044\u308b\u60a3\u8005\uff08\u6b7b\u4ea1\u3057\u305f\u4eba\uff09\u306e\u5fae\u751f\u7269\u76f8\u306e\u5909\u5316\u3092\u8abf\u3079\u3066\u304d\u307e\u3057\u305f\u3002\u5fae\u751f\u7269\u53e2\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u3088\u308a\u3001\u5171\u751f\u7d30\u83cc\u306e\u4e3b\u306a\u30d5\u30a1\u30df\u30ea\u30fc\u3067\u3042\u308b\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u3068\u4e73\u9178\u83cc\u306e\u5927\u5e45\u306a\u6e1b\u5c11\u3001\u304a\u3088\u3073\u30b3\u30ea\u30cd\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u3084\u30eb\u30c6\u30cb\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u306a\u3069\u306e\u65e5\u548c\u898b\u7d30\u83cc\u306e\u5897\u52a0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\uff09\u201d
\u21d2\u305d\u306e\u3055\u3089\u306b\u5143\u8cc7\u6599\u304c\u3053\u308c\uff1aImmunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019<\/a>

\u201dLes lipopolysaccharides (LPS), molecules produites par les bacteries a gram negatif, entrainent l\u2019instauration d\u2019un climat pro-inflammatoire dans l\u2019ensemble de l\u2019organisme.
\uff08\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u304c\u7523\u751f\u3059\u308b\u5206\u5b50\u3067\u3042\u308b\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u306f\u3001\u5168\u8eab\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\uff09\u201d
\u21d2\u3053\u308c\u306f\u3001\u4ee5\u524d\u300e\u8178\u3068\u8133\u300f\u306b\u3082\u66f8\u3044\u3066\u307e\u3057\u305f\u3002

\u201dDe nombreuses etudes ont montre que le microbiote des personnes agees compte davantage de bacteries gram negatif, ce qui a pour consequence d\u2019augmenter les taux de LPS et par consequent, de permeabilite intestinale et de risque inflammatoire.
\uff08\u591a\u6570\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u9ad8\u9f62\u8005\u306e\u5fae\u751f\u7269\u76f8\u306b\u306f\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u304c\u591a\u304f\u3001\u3053\u308c\u306b\u3088\u308aLPS\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u3001\u8178\u306e\u900f\u904e\u6027\u3068\u708e\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff09\u201d
\u21d2\u3053\u308c\u3082\u300e\u8178\u3068\u8133\u300f\u306b\u66f8\u304b\u308c\u3066\u3044\u307e\u3057\u305f\u3002

\u3053\u3053\u3067\u3001\u5168\u8eab\u7684\u306a\u708e\u75c7\u6027\u306e\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u3068\u3057\u3066\u3001
Prevotella\u83cc\u304c\u767b\u5834\u3057\u307e\u3059\u3002
\u306a\u305c\u30d7\u30ec\u30dc\u30c6\u30e9\u83cc\u306a\u306e\u304b\uff1f\u3067\u3059\u304c\u3001
\u3053\u3093\u306a\u8ad6\u6587\u304c\u3042\u308b\u69d8\u3067\u3059\u3002
\u201dSARS-Cov2 enables anaerobic bacteria (Prevotella, et al) to colonize the lungs disrupting homeostasis – symptoms (ARDS, septic shock, blood clots, arterial stroke) finds resonance, with key differences, in the \u2018forgotten disease\u2019 Lemierre Syndrome, caused by anaerobic bacteria enabled by Epstein Barr Virus\u201d
\uff1ehttps:\/\/<\/a>osf.io\/usztn\/<\/a>

\u4e0a\u6c17\u9053\u708e\u304b\u3089\u7d9a\u767a\u3059\u308b\u75c5\u6c17\u306b\u5185\u981a\u9759\u8108\u8840\u6813\u75c7\u304c\u3042\u308a\u3001
\u3053\u308c\u3092\u30ec\u30df\u30a8\u30fc\u30eb\u75c7\u5019\u7fa4\u3068\u8a00\u3046\u306e\u3067\u3059\u304c\u3001
\u3053\u306e\u75c5\u6c17\u306bEB\u30a6\u30a4\u30eb\u30b9\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3089\u3057\u3044\u306e\u3067\u3059\u304c\u3001
\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-Cov2\uff09\u3082\u4f3c\u305f\u3088\u3046\u306a\u6a5f\u5e8f\u3067\u3001
Prevotella\u83cc\u306a\u3069\u306e\u5acc\u6c17\u6027\u83cc\u306b\u3088\u3063\u3066\u3001
\u80ba\u3060\u3051\u3067\u306a\u304f\u5168\u8eab\u3092\u91cd\u75c7\u5316\u3055\u305b\u3066\u3057\u307e\u3046\u306e\u3067\u306f\u306a\u3044\u304b\u3001
\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002

\u305f\u3060\u3001\u3053\u306e\u8ad6\u6587\u306f\u3001
\u80ba\u306bSARS-Cov2\u304c\u3084\u3063\u3066\u304d\u3066\u3001\u305d\u3053\u306b\u3044\u305fPrevotella\u83cc\u304c
\u60aa\u3055\u3092\u3059\u308b\u3001\u3068\u3044\u3046\u69d8\u306b\u8aad\u3093\u3060\u306e\u3067\u3059\u304c\u3001
\uff08\u50d5\u304c\u8aad\u307f\u9593\u9055\u3048\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\uff09
\u9023\u65e5\u30c6\u30ec\u30d3\u306a\u3069\u3067\u3082\u5831\u9053\u3055\u308c\u3066\u3044\u305fCOVID-19\u306e
\u80ba\u708e\u50cf\u306f\u7d30\u83cc\u6027\u3067\u306f\u306a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002

\u660e\u65e5\u306b\u7d9a\u304f<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6628\u65e5\u304b\u3089\u306e\u7d9a\u304d\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306a\u306e\u306b\u306a\u305c\u6297\u751f\u7269\u8cea\uff1f\u305d\u306e\u5143\u30cd\u30bf\u3067\u3059\u3002 Covid-19 : la piste du microbiote, vers un nouveau paradigme ?\uff08Covid-19\uff1a\u5fae\u751f\u7269\u53e2\u30c8 …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89,6],"tags":[67,66],"class_list":["post-6927","post","type-post","status-publish","format-standard","hentry","category-covid-19","category-blog","tag-covid-19","tag-66"],"_links":{"self":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6927"}],"version-history":[{"count":5,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6927\/revisions"}],"predecessor-version":[{"id":6970,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6927\/revisions\/6970"}],"wp:attachment":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}