
{"id":6915,"date":"2020-06-03T08:28:00","date_gmt":"2020-06-02T23:28:00","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=6915"},"modified":"2020-05-31T13:26:51","modified_gmt":"2020-05-31T04:26:51","slug":"2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%ae%e7%97%85%e6%85%8b%e7%94%9f%e7%90%86%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%85%b8%e5%86%85%e5%be%ae%e7%94%9f%e7%89%a9%e5%8f%a2%e3%81%ae%e5%bd%b9%e5%89%b2","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=6915","title":{"rendered":"II\u578b\u7cd6\u5c3f\u75c5\u306e\u75c5\u614b\u751f\u7406\u306b\u304a\u3051\u308b\u8178\u5185\u5fae\u751f\u7269\u53e2\u306e\u5f79\u5272"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u6b21\u306f\u8178\u5185\u5fae\u751f\u7269\u53e2\u3068II\u578b\u7cd6\u5c3f\u75c5\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059\u3002<br><br><a aria-label=\"Role of gut microbiota in type  2 diabetes pathophysiology (\u65b0\u3057\u3044\u30bf\u30d6\u3067\u958b\u304f)\" rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5846192\/\" target=\"_blank\">Role of gut microbiota in type  2 diabetes pathophysiology<\/a><br>Manoj Gurunga, Zhipeng Lia, Hannah Youa, Richard  Rodriguesb, Donald B Jumpc, Andrey Morgunb, Natalia Shulzhenko<br>National  Center for Biotechnology Information, U.S. National Library of  Medicine<br>II\u578b\u7cd6\u5c3f\u75c5\u3068\u7d30\u83cc\u306e\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3092\u8abf\u67fb\u3057\u305f\u89b3\u5bdf\u7814\u7a76\uff1a<br>\u5171\u901a\u306e\u8a8d\u8b58\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001<br>\u30d3\u30d5\u30a3\u30c9\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u5c5e\uff08\u3044\u308f\u3086\u308b\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u3001<br>\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u5c5e\u3001\u30d5\u30a7\u30ab\u30ea\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u5c5e\u3001\u30a2\u30c3\u30ab\u30fc\u30de\u30f3\u30b7\u30a2\u5c5e<br>\u304a\u3088\u3073\u30ed\u30fc\u30ba\u30d6\u30ea\u30a2\u5c5e\u306f<br>II\u578b\u7cd6\u5c3f\u75c5\u3068\u8ca0\u306e\u95a2\u9023\uff08\u83cc\u304c\u5c11\u306a\u3044\u3068\u5897\u60aa\uff09\u304c\u3042\u308a\u3001<br>\u30eb\u30df\u30ce\u30b3\u30c3\u30ab\u30b9\u5c5e\u3001\u30d5\u30bd\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u5c5e\u3068\u30d6\u30e9\u30a6\u30c6\u30a3\u30a2\u5c5e\u306f<br>\u6b63\u306e\u95a2\u9023\uff08\u83cc\u304c\u5897\u3048\u308b\u3068\u5897\u60aa\uff09\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002<br><br>\u30e9\u30af\u30c8\u30d0\u30b7\u30eb\u30b9\u5c5e\uff08\u4e73\u9178\u83cc\u5c5e\uff09\u306eII\u578b\u7cd6\u5c3f\u75c5\u306b\u95a2\u3057\u3066\u306e\u8a8d\u8b58\u306f\u3001<br>\u5b8c\u5168\u306b\u306f\u4e00\u81f4\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u30016\u3064\u306e\u8ad6\u6587\u306e\u3046\u30615\u3064\u306e\u8ad6\u6587\u3067<br>\u6b63\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002<br><br>\u3055\u3066\u3001\u3053\u306e\u3088\u3046\u306bII\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u3067\u306f\u7cd6\u5c3f\u75c5\u3067\u306a\u3044\u4eba\u3068\u6bd4\u3079<br>\u8178\u5185\u3067\u306e\u5fae\u751f\u7269\uff08\u4e3b\u306b\u7d30\u83cc\uff09\u306e\u7a2e\u985e\u306e\u6bd4\u7387\u304c\u5909\u308f\u3063\u3066\u3044\u307e\u3059\u3002<br>\u3053\u306e\u5fae\u751f\u7269\u53e2\u304c\u4ee3\u8b1d\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u3082<br>\u5f90\u3005\u306b\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<br><br>\u5fae\u751f\u7269\u53e2\u306f\u3001\u708e\u75c7\u3092\u8abf\u7bc0\u3057\u3001\u98df\u4e8b\u6210\u5206\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001<br>\u8178\u306e\u900f\u904e\u6027\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u304a\u3088\u3073\u8102\u8cea\u4ee3\u8b1d\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3001<br>\u304a\u3088\u3073\u5bbf\u4e3b\u306e\u5168\u4f53\u7684\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u6052\u5e38\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305d\u3046\u3067\u3059\u3002<br><br>\u305f\u3068\u3048\u3070\u3001\u4e73\u9178\u687f\u83cc  Lactobacillus\u5c5e\u306eL.paracasei \u3084\u3001<br>Bacteroides\u5c5e\u306eB.  fragilis\u306f\u3001<br>\u4eca\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u7b2c2\u76f8\u3067\u751f\u3058\u308b<br>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306b\u95a2\u9023\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308bIL-6\u306e\u767a\u73fe\u3092<br>\u963b\u5bb3\u3059\u308b\u3088\u3046\u3067\u3059\u3002<br>\u4ed6\u306b\u3082\u6709\u76ca\u306a\u5fae\u751f\u7269\u306f\u708e\u75c7\u3092\u9632\u3050\u65b9\u5411\u306b\u50cd\u304f\u69d8\u3067\u3059\u3002<br><br>\u9006\u306b\u3001\u6f5c\u5728\u7684\u306b\u6709\u5bb3\u306a\u5fae\u751f\u7269\u306f\u3001\u4ed6\u306e\u708e\u75c7\u6027\u75be\u60a3\u3067\u306e\u8a71\u3067\u3059\u304c\u3001<br>\u3044\u304f\u3064\u304b\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5897\u52a0\u3055\u305b\u3066\u3044\u308b<br>\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br>\u7279\u306b\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u306f\u4ee3\u8b1d\u6027\u5185\u6bd2\u7d20\u8840\u75c7\u3068\u8efd\u5ea6\u306e\u708e\u75c7\u3092<br>\u4fc3\u9032\u3055\u305b\u308b\u65b9\u5411\u306b\u50cd\u304d\u307e\u3059\u3002<br><br>\u305d\u306e\u4ed6\u3001\u8178\u900f\u904e\u6027\u306b\u3064\u3044\u3066\u3082\u8003\u5bdf\u304c\u3042\u308a\u307e\u3059\u3002<br>II\u578b\u7cd6\u5c3f\u75c5\u3067\u306f\u3001\u8178\u900f\u904e\u6027\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u305d\u3046\u3067\u3001<br>\u305d\u306e\u7d50\u679c\u3001\u8178\u5185\u5fae\u751f\u7269\u7523\u7269\u304c\u8840\u6db2\u4e2d\u306b\u79fb\u884c\u3057\u3001<br>\u4ee3\u8b1d\u6027\u5185\u6bd2\u7d20\u8840\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br>\u305f\u3068\u3048\u3070\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\uff08Bacteroides  vulgatus \u3068 B. dorei\uff09\u3084\u3001<br>Akkermansia  muciniphila\u306f\u3001\u7d50\u8178\u306e\u7d30\u80de\u7d50\u5408\u3092\u5f37\u304f\u3057\u3066\u3001<br>\u8178\u900f\u904e\u6027\u306e\u4f4e\u4e0b\u3001LPS\u7523\u751f\u3092\u4f4e\u4e0b\u3055\u305b\u3001<br>\u5185\u6bd2\u7d20\u8840\u75c7\u306e\u6539\u5584\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<br><br>\u3055\u3089\u306b\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4ee3\u8b1d\u7523\u7269\u306f\u3001\u809d\u81d3\u3001\u7b4b\u8089\u3001\u8102\u80aa\u306a\u3069\u306e<br>\u4ee3\u8b1d\u5668\u5b98\u306b\u50cd\u304d\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u6052\u5e38\u6027\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306b<br>\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u307e\u305f\u9006\u306b\u7cd6\u306e\u6d88\u5316\u3092\u5236\u5fa1\u3059\u308b<br>\u8178\u30db\u30eb\u30e2\u30f3\u306e\u7523\u751f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001<br>II\u578b\u7cd6\u5c3f\u75c5\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002<br><br>\u307e\u305f\u3001\u8102\u80aa\u9178\u306e\u9178\u5316\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u306e\u5897\u52a0\u3068\u3001<br>\u8102\u80aa\u9178\u306e\u5408\u6210\u306e\u6e1b\u5c11\u306b\u3088\u3063\u3066\u3001\u80a5\u6e80\u304c\u6539\u5584\u3057\u3001<br>\u305d\u306e\u7d50\u679cII\u578b\u7cd6\u5c3f\u75c5\u3082\u6539\u5584\u3059\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u304c\u3001<br>\u305d\u3046\u3057\u305f\u8102\u80aa\u9178\u306e\u4ee3\u8b1d\u306b\u3001Akkermansia  muciniphila\u3001<br>Bacteroides acidifaciens\u3001Lactobacillus  gasseri<br>\u3068\u3044\u3063\u305f\u7d30\u83cc\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3060\u305d\u3046\u3067\u3059\u3002<br><br>\u50d5\u306f\u3053\u306e\u5206\u91ce\u306f\u5c02\u9580\u3067\u306f\u306a\u3044\u306e\u3067\u3001<br>\u5927\u96d1\u628a\u306a\u8a71\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u304c\u3001<br>\u8981\u306f\u3001\u6709\u76ca\u306a\u7d30\u83cc\u7b49\u304c\u8178\u5185\u304b\u3089\u5c11\u306a\u304f\u306a\u308b\u3068II\u578b\u7cd6\u5c3f\u75c5\u306b<br>\u306a\u308a\u3084\u3059\u3044\u3057\u3001\u60aa\u7389\u306e\u5fae\u751f\u7269\u304c\u5897\u3048\u3066\u304f\u308b\u3068\u3001<br>\u7cd6\u4ee3\u8b1d\u3084\u8102\u80aa\u9178\u306e\u4ee3\u8b1d\u304c\u60aa\u3044\u65b9\u5411\u306b\u50cd\u304d\u3001<br>\u8178\u306e\u30d0\u30ea\u30a2\u3082\u5f31\u304f\u306a\u3063\u3066\u3044\u308d\u3044\u308d\u306a\u8178\u5185\u5fae\u751f\u7269\u306e\u4ee3\u8b1d\u7523\u7269\u304c<br>\u4f53\u4e2d\u3092\u5de1\u308b\u3053\u3068\u306b\u306a\u308a\u3001\u4f53\u4e2d\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u8003\u3048\u3089\u308c\u308b<br>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6b21\u306f\u8178\u5185\u5fae\u751f\u7269\u53e2\u3068II\u578b\u7cd6\u5c3f\u75c5\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3067\u3059\u3002 Role of gut microbiota in type 2 diabetes pathophysiologyManoj Gurunga, Zhipeng Lia, &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[66],"class_list":["post-6915","post","type-post","status-publish","format-standard","hentry","category-blog","tag-66"],"_links":{"self":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6915"}],"version-history":[{"count":2,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6915\/revisions"}],"predecessor-version":[{"id":6917,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=\/wp\/v2\/posts\/6915\/revisions\/6917"}],"wp:attachment":[{"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itaya.or.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}