{"id":5025,"date":"2018-11-04T08:28:35","date_gmt":"2018-11-03T23:28:35","guid":{"rendered":"http:\/\/www.itaya.or.jp\/?p=5025"},"modified":"2018-11-03T03:33:30","modified_gmt":"2018-11-02T18:33:30","slug":"%e7%ac%ac10%e5%9b%9e%e6%97%a5%e6%9c%ac%e8%80%b3%e9%bc%bb%e5%92%bd%e5%96%89%e7%a7%91%e5%bf%83%e8%ba%ab%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e4%bc%9a3","status":"publish","type":"post","link":"https:\/\/www.itaya.or.jp\/?p=5025","title":{"rendered":"\u7b2c10\u56de\u65e5\u672c\u8033\u9f3b\u54bd\u5589\u79d1\u5fc3\u8eab\u533b\u5b66\u7814\u7a76\u4f1a3"},"content":{"rendered":"

\u6628\u65e5\u304b\u3089\u306e\u3064\u3065\u304d<\/span><\/p>\n

\u6b21\u306b\u3001\u6700\u8fd1\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u201d\u8133\u30fb\u8178\u30fb\u7d30\u83cc\u76f8\u95a2\u201d\u306b\u3064\u3044\u3066<\/span>\u3002
\n<\/span><\/p>\n

\n
\n
\n

\u8178\u5185\u7d30\u83cc\u305d\u306e\u3082\u306e\u3082\u3001\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u3046\u3051\u3066\u3044\u308b<\/span>\u3002
\n\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u4ea4\u611f\u795e\u7d4c\u304c\u6d3b\u6027\u5316\u304c\u8d77\u308b\u3002
\n\u21d2\u5206\u6ccc\u3055\u308c\u305f\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u304c\u7d30\u83cc\u306eQseC\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u3001
\n\u21d2\u7d30\u83cc\u304b\u3089\u3044\u308d\u3044\u308d\u306a\u7269\u8cea\u304c\u5206\u6ccc\u3055\u308c\u308b\u3002
\n\u21d2\u5206\u6ccc\u3055\u308c\u305f\u7269\u8cea\u306f\u8178\u306e\u7d30\u80de\u306e\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3001
\n\u7d30\u83cc\u306e\u5897\u6b96\u306b\u6709\u5229\u306b\u50cd\u304f\u3002
\n\u3053\u308c\u306f\u3001\u8178\u3060\u3051\u3067\u306a\u304f\u3001\u54bd\u982d\u3084\u9f3b\u8154\u306e\u7d30\u83cc\u3067\u3082\u540c\u3058\u69d8\u306a\u3053\u3068\u304c<\/span>
\n \u8d77\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/span>\u3002<\/span><\/p>\n

\u305f\u3068\u3048\u3070\u3001\u9162\u9178\u304c\u5897\u3048\u308b\u3068IBS\u304c\u91cd\u75c7\u5316\u3059\u308b\u3002<\/p>\n

\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u75be\u60a3\u306e\u6e90\u6d41\u306b\u306fDNA\u306e\u30e1\u30c1\u30eb\u5316<\/span>\u304c\u3042\u308b\u306e\u3067\u306f\uff1f
\n\u52d5\u7269\u5b9f\u9a13\uff1a
\n\u751f\u307e\u308c\u305f\u3066\u306e\u5b50\u3069\u3082\u306f\u3001\u6bcd\u89aa\u304b\u3089\u306e\u30b1\u30a2\u306e\u3055\u308c\u65b9\u3067\u3001
\n\u8074\u6027\u8133\u5e79\u53cd\u5fdc\u306e\u6f5c\u6642\u306f\u5909\u5316\u3059\u308b\u3002
\n\u30de\u30bf\u30fc\u30ca\u30eb\u30b1\u30a2\u304c\u5341\u5206\u306b\u306a\u3055\u308c\u306a\u3044\u3068DNA\u304c\u30e1\u30c1\u30eb\u5316\u3002
\n\uff08\u3053\u3053\u306b\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u95a2\u4e0e\uff1f\uff09
\n\u21d2\u6d77\u99ac\u3067\u306e\u30b0\u30eb\u30b3\u30b3\u30a4\u30c9\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u767a\u73fe\u2193
\n\u21d2\u526f\u814e\u76ae\u8cea\u30db\u30eb\u30e2\u30f3\u306e\u6fc3\u5ea6\u2191\u3001\u4e0d\u5b89\u2191\u3001\u6b21\u306e\u4e16\u4ee3\u306e\u30b1\u30a2\u2193
\n\u4eca\u5f8c\u4eba\u306e\u4e2d\u3067\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u89e3\u660e\u304c\u91cd\u8981\u8996\u3002<\/p>\n

\u6241\u6843\u4f53\u6a5f\u80fd\u3092PET\u3067\u78ba\u8a8d<\/span>
\nCRH\u306e\u6295\u4e0e\u3067\u6241\u6843\u4f53\u306e\u6d3b\u6027\u5316\u304c\u7279\u7570\u7684\u306b\u304a\u3053\u3063\u3066\u304f\u308b\u3002
\n\u3053\u3053\u306b\u3067\u5927\u8178\u3092\u81a8\u3089\u307e\u305b\u308b\u523a\u6fc0\u3092\u3059\u308b\u3068\u3001
\n\u5065\u5e38\u8005\u306f\u3055\u3089\u306b\u53cd\u5fdc\u3059\u308b\u304c\u3001IBS\u60a3\u8005\u3067\u306f\u3001
\n\u3081\u3044\u3044\u3063\u3071\u3044\u53cd\u5fdc\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u305d\u308c\u4ee5\u4e0a\u53cd\u5fdc\u304c\u4e0a\u304c\u3089\u306a\u3044\u3002<\/p>\n

CRH\u6295\u4e0e\u6642\u306e\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3092\u6e2c\u5b9a
\n\u6241\u6843\u4f53\u306e\u5909\u52d5\u3068\u30d1\u30e9\u30ec\u30eb\u306a\u5909\u52d5\u304c\u307f\u3089\u308c\u308b\u3002<\/p>\n

\u3081\u307e\u3044\u306a\u3069\u306b\u751f\u3058\u308b\u6050\u6016\u611f\u899a<\/span>
\nKandel\uff08\u30ce\u30fc\u30d9\u30eb\u8cde\u53d7\u8cde\u8005\uff09\u306e\u63d0\u5531\u3059\u308b\u30d1\u30e9\u30c0\u30a4\u30e0\uff1a
\n\u8074\u899a\u523a\u6fc0\u304b\u3089\u76ae\u8cea\u306b\u523a\u6fc0\u304c\u4f1d\u9054
\n\u21d2\u305d\u306e\u5f8c\u3001\u6241\u6843\u4f53\u57fa\u5e95\u5916\u5074\u6838\u3067\u306b\u307e\u3067\u30b7\u30b0\u30ca\u30eb\u304c\u4f1d\u9054\u3057\u3055\u308c\u3001
\n\u60c5\u5831\u304c\u5408\u308f\u3055\u308a\u9023\u52d5\u3055\u308c\u308b\u3068\u6050\u6016\u6761\u4ef6\u4ed8\u3051\u304c\u751f\u3058\u308b<\/span>\u3002
\n\u2193
\n\u3053\u308c\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u306f\u3001\u5fc5\u305a\u3042\u308b\u5185\u7684\u306a\u6761\u4ef6\u4ed8\u3051\u304c\u306a\u3044\u3068\u8d77\u3089\u306a\u3044
\n\u5185\u7684\u306a\u523a\u6fc0\u3068\u5916\u304b\u3089\u306e\u611f\u899a\u304c\u5408\u308f\u3055\u308b\u3053\u3068\u306b\u3088\u3063\u3066<\/span>
\n \u6050\u6016\u306e\u3088\u3046\u306a\u9670\u6027\u75c7\u72b6\u306e\u6e90\u6d41\u304c\u751f\u3058\u308b<\/span>\u3002
\n\u2193
\n\u6241\u6843\u4f53\u306e\u4e2d\u5fc3\u6838\u304b\u3089\u3001
\nBehavioral\u30fbAutonomical\u30fbEndocrine\u306a\u3069\u3092\u901a\u3057\u3066\u5168\u8eab\u306b\u3002<\/p>\n

\u3053\u3046\u3057\u305f\u6761\u4ef6\u4ed8\u3051\u306f\u3001\u4e0d\u78ba\u304b\u3055\u3082\u95a2\u4e0e<\/span>\u3059\u308b\u3002
\n1\uff09\u8996\u899a\u523a\u6fc0\u304c\u751f\u3058\u305f\u3089\u5fc5\u305a\u5185\u81d3\u523a\u6fc0\u3092\u3059\u308b\uff08\u78ba\u304b\uff09
\n2\uff09\u8996\u899a\u523a\u6fc0\u304c\u751f\u3058\u305f\u3089\u5fc5\u305a\u5185\u81d3\u523a\u6fc0\u304c\u3053\u306a\u3044\uff08\u9670\u6027\uff09
\n3\uff09\u8996\u899a\u523a\u6fc0\u304c\u751f\u3058\u3066\u3082\u5185\u81d3\u523a\u6fc0\u306f\u6765\u308b\u304b\u6765\u306a\u3044\u304b\u308f\u304b\u3089\u306a\u3044\uff08\u4e0d\u78ba\u304b\uff09
\n\u21d23\uff09\u304c\u6700\u3082\u5927\u304d\u3044
\n\u2193
\n\u4e0d\u78ba\u304b\u30fc\u78ba\u304b\u306e\u53cd\u5fdc\u5dee\u306fIBS\u60a3\u8005\u306e\u65b9\u304c\u306f\u308b\u304b\u306b\u306b\u5927\u304d\u3044\u3002
\n\u21d2\u75db\u307f\u3092\u611f\u3058\u308b\u4e2d\u90e8\u306e\u5e2f\u72b6\u56de\u3001precuneus\u3001\u5f8c\u90e8\u5e2f\u72b6\u56de\u304c\u6d3b\u6027\u5316
\n\u75db\u307f\u3092\u51e6\u7406\u3059\u308b\u90e8\u5206\u3067\u611f\u4f5c\u304c\u8d77\u3063\u3066\u3044\u308b<\/span>\u3002<\/p>\n

IBS\u306b\u304a\u3044\u3066\u30b2\u30ce\u30e0\u306e\u7814\u7a76<\/span>
\nCRH\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u95a2\u4fc2<\/span>\u3057\u3066\u3044\u308b\u3002
\n\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u8d77\u3053\u3059\u90e8\u5206\u3067\u5909\u7570\u304c\u8d77\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3002<\/p>\n

\u3053\u308c\u306f5\uff0dHT\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\uff09\u306eTransporter\u907a\u4f1d\u5b50\u3067\u3082\u307f\u3089\u308c\u308b\u3002
\n\u305d\u3057\u3066\u3001\u3053\u306e\u30b2\u30ce\u30e0\u4f9d\u5b58\u578b\u306e\u53cd\u5fdc\u306f\u3001\u3042\u308b\u7279\u5b9a\u306e\u30b2\u30ce\u30e0\u3067\u304a\u3053\u308b\u3002
\n\u305d\u308c\u306f\u8133\u306e\u4e2d\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u7a0b\u5ea6\u306b\u3088\u3063\u3066\u3082\u9055\u3046\u3002<\/p>\n

IBS\uff1aEvidence\u306b\u57fa\u3065\u304f\u533b\u7642\u30fb\u30fb\u30fb\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/span>
\nRamosteron\u3068\u3044\u3046\u85ac\u306e\u52b9\u679c\u306b\u3064\u3044\u3066\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a
\nplacebo\u3067\u308220-30\uff05\u306e\u594f\u529f\u7387\u304c\u3042\u308a\u3001
\n\u5b9f\u85ac\u3092\u4f7f\u3046\u3068\u3001\u305d\u308c\u306b20\uff05\u8fd1\u3044\u306e\u4e0a\u4e57\u305b\u52b9\u679c\u304c\u3067\u3066\u304f\u308b\u3002
\n\u2193
\n\u6ce8\u76ee\u70b9\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u52b9\u679c\u304c20-30\uff05\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3002
\n\u3082\u3057\u30d7\u30e9\u30bb\u30dc\u52b9\u679c\u304c\u306a\u3051\u308c\u3070\u3001
\n\u5b9f\u85ac\u3067100\u4eba\u4e2d\u306e20\u4eba\u306b\u3057\u304b\u52b9\u679c\u304c\u51fa\u305b\u306a\u3044\u3053\u3068\u306b\u306a\u308b\u3002
\n\u3064\u307e\u308a\u3001\u81e8\u5e8a\u533b\u306f\u3053\u306e\u30d7\u30e9\u30bb\u30dc\u52b9\u679c\u3082\u5927\u5207\u306b\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044<\/span>\u3002<\/p>\n

\uff1e\u3053\u308c\u306f\u50d5\u3082\u305d\u3046\u601d\u3044\u307e\u3059\u3002
\n\u30d7\u30e9\u30bb\u30dc\u3067\u3082\u6cbb\u305b\u308b\u306e\u304c\u3044\u3044\u533b\u8005\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u5fc3\u7406\u7642\u6cd5<\/span>
\nIBS\u306b\u5bfe\u3059\u308b\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5<\/span>\u30fb\u30fb\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u8a3c\u660e
\n\u96e3\u6cbb\u6027IBS\u306b\u5bfe\u3059\u308b\u81ea\u5f8b\u8a13\u7df4\u6cd5<\/span>\u3082\u52b9\u679c\u3092\u8a3c\u660e
\n\u21d2\u4eca\u307e\u3067\u6697\u793a\u306a\u3069\u306f\u8efd\u8996\u3055\u308c\u3066\u304d\u305f\u3002
\n\u3057\u304b\u3057\u3001\u5185\u81d3\u611f\u899a\u3084\u81ea\u5f8b\u795e\u7d4c\u6a5f\u80fd\u306a\u3069\u306b\u306f\u3001<\/span>
\n \u30c8\u30c3\u30d7\u30c0\u30a6\u30f3\u5236\u5fa1\u304c\u6709\u7528<\/span>\u306a\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\u3002<\/p>\n

\u76f4\u8178\u306b30\uff4dA\u306e\u96fb\u6c17\u523a\u6fc0\uff08\u75db\u307f\u523a\u6fc0\uff09
\n\u21d2\u93ae\u75db\u6697\u793a\u3092\u52a0\u3048\u308b\u3068\u75db\u307f\u611f\u899a\u306f\u8efd\u304f\u306a\u308b<\/span>\u3002<\/p>\n

\uff1e\u3064\u307e\u308a\u3001\u300c\u30a4\u30bf\u30a4\u3082\u30a4\u30bf\u30a4\u306e\u98db\u3093\u3067\u3051\uff5e\uff01\u300d
\n\u3068\u3044\u3046\u306e\u306f\u610f\u5473\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304b\u306a<\/p>\n

IBS\u3068\u524d\u982d\u524d\u91ce<\/span>
\nIBS\u3067\u306f\u524d\u982d\u524d\u91ce\u306e\u30dc\u30ea\u30e5\u30fc\u30e0\u306e\u6e1b\u5c11\u304c\u8d77\u3063\u3066\u3044\u308b<\/span>\u3002
\nIBS\u306f\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u3067\u3082\u3042\u308b\u3002
\nIBS\u306e\u4eba\u305f\u3061\u306b\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u307f\u308b\u691c\u67fbWisconsin Card Sorting Test
\n\u21d2\u5065\u5e38\u8005\u306f\u9593\u9055\u308f\u306a\u3044\u306e\u306b\u8aa4\u7b54\u304c\u591a\u3044
\n\u3053\u308c\u3092functional MRI\u3067\u691c\u8a0e
\n\u21d2\u5065\u5e38\u8005\u3067\u306f\u524d\u982d\u524d\u91ce\u304c\u6d3b\u6027\u5316\u3059\u308b\u306e\u306b\u3001
\nIBS\u60a3\u8005\u3067\u306f\u6d3b\u6027\u5316\u3055\u308c\u306a\u3044\u3002
\n\u3053\u308c\u304c\u3001\u5927\u304d\u306a\u9593\u9055\u3044\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u6e90\u6d41\u3067\u3042\u308a\u3001
\n\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u3084\u3059\u3044\u611f\u53d7\u6027\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3002<\/p>\n

\u3053\u308c\u3092\u3088\u304f\u3059\u308b\u306b\u306f\u3001<\/span>
\n \u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u306e\u3088\u3046\u306a\u30b9\u30c8\u30ec\u30b9\u4f4e\u6e1b\u30d7\u30ed\u30b0\u30e9\u30e0\u3092<\/span>\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067
\n\u6539\u5584\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3044\u308f\u308c\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n

\u9670\u6027\u60c5\u52d5\u3092\u51e6\u7406\u3059\u308b\u306b\u306f\u3001
\n\u5e2f\u72b6\u56de\u30fb\u80cc\u5916\u5074\u524d\u982d\u524d\u91ce\u306e\u6a5f\u80fd\u3092\u3046\u307e\u304f\u4e0a\u3052\u3001\u6241\u6843\u4f53\u7b49\u3092\u6291\u5236\u3059\u308b
\n\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u63d0\u4f9b\u3059\u308b\u3068\u3088\u3044\u3002
\n\u305d\u306e\u4e00\u3064\u306b\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9<\/span>\u304c\u6709\u7528\u3002
\n\u4ed6\u306br-TMS\uff08\u78c1\u6c17\u523a\u6fc0\uff09\u3067\u3082\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n

IBS\u306e\u767a\u751f\u6a5f\u5e8f\u306b\u95a2\u3059\u308b\u30d1\u30e9\u30c0\u30a4\u30e0<\/span>\uff1a
\n\u8178\u5185\u7d30\u83cc\u306e\u5909\u5316\u21d2\u7c98\u819c\u900f\u904e\u6027\u2191\u21d2\u5fae\u5c11\u708e\u75c7
\n\u21d2IL-6\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u3046\u3064\u306b\u3082\u95a2\u4fc2\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u2191
\n\u21d2\u795e\u7d4c\u611f\u4f5c\u3092\u4ecb\u3057\u3066\u4e2d\u67a2\u795e\u7d4c\u306e\u6a5f\u80fd\u306e\u5909\u5316\u21d2\u5185\u81d3\u77e5\u899a\u2191<\/p>\n

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\n\u3053\u306e\u611f\u899a\u304cParabrachial Nucleus\u304b\u3089
\n\u6241\u6843\u4f53\u30fb\u8996\u5e8a\u4e0b\u90e8\u306b\u76f4\u63a5\u304f\u308b\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3002
\n\u21d2\u3053\u3046\u3057\u305f\u30d1\u30e9\u30c0\u30a4\u30e0\u306f\u8033\u9f3b\u54bd\u5589\u79d1\u75be\u60a3\u3067\u3082
\n\u3069\u306e\u3088\u3046\u306b\u8d77\u3063\u3066\u304f\u308b\u304b\u3068\u3044\u3046\u7814\u7a76\u304c\u307e\u305f\u308c\u308b\u3002<\/p>\n

\u8133\u79d1\u5b66\u304c\u652f\u6301\u3059\u308b\u5fc3\u8eab\u533b\u5b66<\/span>
\nAntonio R Damasio\uff1aDescartes’ Error
\n\u30c7\u30ab\u30eb\u30c8\u306f\u5049\u5927\u306a\u79d1\u5b66\u8005\u3060\u304c\u3001
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\n \u5b9f\u306f\u6b63\u3057\u304b\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b<\/span>\u3002
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\nA\uff09\u81e8\u5e8a\u7684\u306b\u306f\u6709\u7528\u3060\u304c\u3001\u8fd1\u5e74\u3001\u79d1\u5b66\u306e\u9032\u6b69\u3088\u308a\u3001\u305d\u3046\u3057\u305f\u5206\u985e\u306f\u30ca\u30f3\u30bb\u30f3\u30b9\u306b\u306a\u3063\u3066\u304d\u3066\u305f<\/span>\u3002\u7cbe\u795e\u79d1\u9818\u57df\u306e\u75be\u60a3\u3067\u3082\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u5909\u5316\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u53b3\u5bc6\u306a\u533a\u5225\u306f\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u304d\u305f\u304b\u3089\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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